14-3-3 sigma positively regulates p53 and suppresses tumor growth.
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Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer14-3-3sigma is a p37 AUF1-binding protein that facilitates AUF1 transport and AU-rich mRNA decayNuclear export regulation of COP1 by 14-3-3σ in response to DNA damageProtein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilonCOP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3σRegulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activationCaspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2Mechanistic differences in the transcriptional activation of p53 by 14-3-3 isoformsExportin 7 defines a novel general nuclear export pathwayA novel degron-mediated degradation of the RTG pathway regulator, Mks1p, by SCFGrr1.Phosphorylation of the histone deacetylase 7 modulates its stability and association with 14-3-3 proteinsConstitutively active FOXO4 inhibits Akt activity, regulates p27 Kip1 stability, and suppresses HER2-mediated tumorigenicity14-3-3σ Gene Loss Leads to Activation of the Epithelial to Mesenchymal Transition Due to the Stabilization of c-Jun ProteinPKCepsilon stimulated arginine methylation of RIP140 for its nuclear-cytoplasmic export in adipocyte differentiation.Down-regulation of 14-3-3 isoforms and annexin A5 proteins in lung adenocarcinoma induced by the tobacco-specific nitrosamine NNK in the A/J mouse revealed by proteomic analysisExcitability in the p53 network mediates robust signaling with tunable activation thresholds in single cellsThe COP9 signalosome subunit 6 (CSN6): a potential oncogeneApoptosis induced by 1,3,6,7-tetrahydroxyxanthone in Hepatocellular carcinoma and proteomic analysis.14-3-3σ regulates β-catenin-mediated mouse embryonic stem cell proliferation by sequestering GSK-3β.The role and regulatory mechanism of 14-3-3 sigma in human breast cancer.14-3-3ζ as a prognostic marker and therapeutic target for cancerAmifostine alleviates radiation-induced lethal small bowel damage via promotion of 14-3-3σ-mediated nuclear p53 accumulationA role of TGFß1 dependent 14-3-3σ phosphorylation at Ser69 and Ser74 in the regulation of gene transcription, stemness and radioresistanceTranscriptional responses to estrogen and progesterone in mammary gland identify networks regulating p53 activity.Higher expression levels of 14-3-3sigma in ductal carcinoma in situ of the breast predict poorer outcome.Protective effect of 14-3-3 antibodies on stressed neuroretinal cells via the mitochondrial apoptosis pathwayPhosphoproteomic identification of targets of the Arabidopsis sucrose nonfermenting-like kinase SnRK2.8 reveals a connection to metabolic processesDysregulation of the PI3K/Akt signaling pathway affects cell cycle and apoptosis of side population cells in nasopharyngeal carcinoma.CSN6 deregulation impairs genome integrity in a COP1-dependent pathwayOverexpression of cytokeratin 17 is associated with the development of papillary thyroid carcinoma and the presence of lymph node metastasis.The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogrammingAkt blocks the tumor suppressor activity of LKB1 by promoting phosphorylation-dependent nuclear retention through 14-3-3 proteins.14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability.Phosphorylation at carboxyl-terminal S373 and S375 residues and 14-3-3 binding are not required for mouse p53 functionOverexpression of 14-3-3σ counteracts tumorigenicity by positively regulating p73 in vivoNucleocytoplasmic Translocation of UBXN2A Is Required for Apoptosis during DNA Damage Stresses in Colon Cancer Cells.
P2860
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P2860
14-3-3 sigma positively regulates p53 and suppresses tumor growth.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
14-3-3 sigma positively regulates p53 and suppresses tumor growth.
@ast
14-3-3 sigma positively regulates p53 and suppresses tumor growth.
@en
type
label
14-3-3 sigma positively regulates p53 and suppresses tumor growth.
@ast
14-3-3 sigma positively regulates p53 and suppresses tumor growth.
@en
prefLabel
14-3-3 sigma positively regulates p53 and suppresses tumor growth.
@ast
14-3-3 sigma positively regulates p53 and suppresses tumor growth.
@en
P2093
P2860
P1476
14-3-3 sigma positively regulates p53 and suppresses tumor growth
@en
P2093
Chih-Hsin Chen
Guillermina Lozano
Heng-Yin Yang
P2860
P304
P356
10.1128/MCB.23.20.7096-7107.2003
P407
P577
2003-10-01T00:00:00Z