14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation
about
Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 bindingMDMX regulation of p53 response to ribosomal stressMDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathwayChk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathwayDeubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1Hdmx modulates the outcome of p53 activation in human tumor cellsRoles of Chk1 in cell biology and cancer therapyPhosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's diseaseMDM2 and MDMX: Alone and together in regulation of p53MDM4 (MDMX) and its Transcript Variants.Heterogeneous in vitro effects of doxorubicin on gene expression in primary human liposarcoma culturesAberrant activation of p53 due to loss of MDM2 or MDMX causes early lens dysmorphogenesis.Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4Protein modifications regulate the role of 14-3-3γ adaptor protein in cAMP-induced steroidogenesis in MA-10 Leydig cells.Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences, interacts with 14-3-3; role of cis-elements and secondary structure.14-3-3Gamma inhibition of MDMX-mediated p21 turnover independent of p53.Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage.Balance of Yin and Yang: ubiquitylation-mediated regulation of p53 and c-MycSignaling to p53: ribosomal proteins find their way.Autoregulatory suppression of c-Myc by miR-185-3p.Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein.The Roles of MDM2 and MDMX Phosphorylation in Stress Signaling to p53.Protein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx.TFIIS.h, a new target of p53, regulates transcription efficiency of pro-apoptotic bax geneInauhzin sensitizes p53-dependent cytotoxicity and tumor suppression of chemotherapeutic agents.IκB kinase β (IKKβ) inhibits p63 isoform γ (TAp63γ) transcriptional activity.Inactivation of oncogenic cAMP-specific phosphodiesterase 4D by miR-139-5p in response to p53 activation.Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinasesTaking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response.AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity.Identification of complex genomic rearrangements in cancers using CouGaRFunctions of MDMX in the modulation of the p53-response.Mdm2 and MdmX partner to regulate p53.Scission of the p53-MDM2 Loop by Ribosomal Proteins.An endothelial cell genetic screen identifies the GTPase Rem2 as a suppressor of p19ARF expression that promotes endothelial cell proliferation and angiogenesis.Regulation of MDM2 Stability After DNA Damage.Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondriaRibosomal proteins L11 and L5 activate TAp73 by overcoming MDM2 inhibition.Ribosomal proteins L5 and L11 co-operatively inactivate c-Myc via RNA-induced silencing complex.Negative auto-regulators trap p53 in their web.
P2860
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P2860
14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation
description
2006 nî lūn-bûn
@nan
2006 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մարտին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
14-3-3gamma binds to MDMX that ...... 1, resulting in p53 activation
@ast
14-3-3gamma binds to MDMX that ...... 1, resulting in p53 activation
@en
14-3-3gamma binds to MDMX that ...... 1, resulting in p53 activation
@en-gb
14-3-3gamma binds to MDMX that ...... 1, resulting in p53 activation
@nl
type
label
14-3-3gamma binds to MDMX that ...... 1, resulting in p53 activation
@ast
14-3-3gamma binds to MDMX that ...... 1, resulting in p53 activation
@en
14-3-3gamma binds to MDMX that ...... 1, resulting in p53 activation
@en-gb
14-3-3gamma binds to MDMX that ...... 1, resulting in p53 activation
@nl
prefLabel
14-3-3gamma binds to MDMX that ...... 1, resulting in p53 activation
@ast
14-3-3gamma binds to MDMX that ...... 1, resulting in p53 activation
@en
14-3-3gamma binds to MDMX that ...... 1, resulting in p53 activation
@en-gb
14-3-3gamma binds to MDMX that ...... 1, resulting in p53 activation
@nl
P2093
P2860
P3181
P356
P1433
P1476
14-3-3gamma binds to MDMX that ...... 1, resulting in p53 activation
@en
P2093
Mu-Shui Dai
Steven Z Lu
Yingming Zhao
Zhijun Luo
P2860
P304
P3181
P356
10.1038/SJ.EMBOJ.7601010
P407
P577
2006-03-22T00:00:00Z