A glutamine residue in the membrane-associating domain of the bovine papillomavirus type 1 E5 oncoprotein mediates its binding to a transmembrane component of the vacuolar H(+)-ATPase.
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The BPV-1 E5 protein, the 16 kDa membrane pore-forming protein and the PDGF receptor exist in a complex that is dependent on hydrophobic transmembrane interactionsEndoplasmic reticulum-localized human papillomavirus type 16 E5 protein alters endosomal pH but not trans-Golgi pH.Structural role of the conserved cysteines in the dimerization of the viral transmembrane oncoprotein E5.Cellular transformation by a transmembrane peptide: structural requirements for the bovine papillomavirus E5 oncoprotein.Mutational analysis of the interaction between the bovine papillomavirus E5 transforming protein and the endogenous beta receptor for platelet-derived growth factor in mouse C127 cells.Mutational analysis of the beta-type platelet-derived growth factor receptor defines the site of interaction with the bovine papillomavirus type 1 E5 transforming protein.E5 oncoprotein transmembrane mutants dissociate fibroblast transforming activity from 16-kilodalton protein binding and platelet-derived growth factor receptor binding and phosphorylation.Mutational analysis of human papillomavirus type 11 E5a oncoproteinHydrophobic Mismatch Drives the Interaction of E5 with the Transmembrane Segment of PDGF Receptor.Transmembrane domain sequence requirements for activation of the p185c-neu receptor tyrosine kinase.The v-sis protein retains biological activity as a type II membrane protein when anchored by various signal-anchor domains, including the hydrophobic domain of the bovine papilloma virus E5 oncoprotein.The bovine papillomavirus type 1 E5 transforming protein specifically binds and activates the beta-type receptor for the platelet-derived growth factor but not other related tyrosine kinase-containing receptors to induce cellular transformation.Specific interaction between the bovine papillomavirus E5 transforming protein and the beta receptor for platelet-derived growth factor in stably transformed and acutely transfected cellsMutation of the bovine papillomavirus E5 oncoprotein at amino acid 17 generates both high- and low-transforming variantsThe genomes of the animal papillomaviruses European elk papillomavirus, deer papillomavirus, and reindeer papillomavirus contain a novel transforming gene (E9) near the early polyadenylation site.Human immunodeficiency virus type 1 Vpu protein is an oligomeric type I integral membrane protein.Transformation-specific interaction of the bovine papillomavirus E5 oncoprotein with the platelet-derived growth factor receptor transmembrane domain and the epidermal growth factor receptor cytoplasmic domainThe human papillomavirus type 6 and 16 E5 proteins are membrane-associated proteins which associate with the 16-kilodalton pore-forming protein.The human T-cell leukemia/lymphotropic virus type I p12I protein cooperates with the E5 oncoprotein of bovine papillomavirus in cell transformation and binds the 16-kilodalton subunit of the vacuolar H+ ATPase.The central hydrophobic domain of the bovine papillomavirus E5 transforming protein can be functionally replaced by many hydrophobic amino acid sequences containing a glutamineBap31 is a novel target of the human papillomavirus E5 protein.Stable association between the bovine papillomavirus E5 transforming protein and activated platelet-derived growth factor receptor in transformed mouse cells.E5 oncoprotein retained in the endoplasmic reticulum/cis Golgi still induces PDGF receptor autophosphorylation but does not transform cellsCompensatory mutants of the bovine papillomavirus E5 protein and the platelet-derived growth factor β receptor reveal a complex direct transmembrane interaction.Golgi alkalinization by the papillomavirus E5 oncoprotein.
P2860
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P2860
A glutamine residue in the membrane-associating domain of the bovine papillomavirus type 1 E5 oncoprotein mediates its binding to a transmembrane component of the vacuolar H(+)-ATPase.
description
1992 nî lūn-bûn
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1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
A glutamine residue in the mem ...... t of the vacuolar H(+)-ATPase.
@ast
A glutamine residue in the mem ...... t of the vacuolar H(+)-ATPase.
@en
type
label
A glutamine residue in the mem ...... t of the vacuolar H(+)-ATPase.
@ast
A glutamine residue in the mem ...... t of the vacuolar H(+)-ATPase.
@en
prefLabel
A glutamine residue in the mem ...... t of the vacuolar H(+)-ATPase.
@ast
A glutamine residue in the mem ...... t of the vacuolar H(+)-ATPase.
@en
P2093
P2860
P1433
P1476
A glutamine residue in the mem ...... t of the vacuolar H(+)-ATPase.
@en
P2093
P2860
P304
P407
P577
1992-01-01T00:00:00Z