The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development. - sprookjes - yvandenbroek - TriplyDB

The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development.

The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development.

http://www.wikidata.org/entity/Q36663184

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The Nodal signaling pathway controls left-right asymmetric development in amphioxus Proteomic and genomic analysis of PITX2 interacting and regulating networks Pitx2 is an upstream activator of extraocular myogenesis and survival Identification of QTL for UV-protective eye area pigmentation in cattle by progeny phenotyping and genome-wide association analysis Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis Gene-Environment Interactions Target Mitogen-activated Protein 3 Kinase 1 (MAP3K1) Signaling in Eyelid Morphogenesis Forces generated by cell intercalation tow epidermal sheets in mammalian tissue morphogenesis.Retinoic acid signaling in perioptic mesenchyme represses Wnt signaling via induction of Pitx2 and Dkk2 Aberrant expression of a beta-catenin gain-of-function mutant induces hyperplastic transformation in the mouse cornea.Disruption of mouse corneal epithelial differentiation by conditional inactivation of pnn.A Chinese family with Axenfeld-Rieger syndrome: report of the clinical and genetic findings Interleukin-1β-induced Wnt5a enhances human corneal endothelial cell migration through regulation of Cdc42 and RhoA.pitx2 Deficiency results in abnormal ocular and craniofacial development in zebrafish The homeodomain transcription factor PITX2 is required for specifying correct cell fates and establishing angiogenic privilege in the developing cornea Eyelid closure in embryogenesis is required for ocular adnexa development Preferential biological processes in the human limbus by differential gene profiling.Multiple requirements of the focal dermal hypoplasia gene porcupine during ocular morphogenesis Effect of PITX2 knockdown on transcriptome of primary human trabecular meshwork cell cultures Wnt ligands from the embryonic surface ectoderm regulate 'bimetallic strip' optic cup morphogenesis in mouse Alcohol and aldehyde dehydrogenases: retinoid metabolic effects in mouse knockout models Overexpression of Pax6 in mouse cornea directly alters corneal epithelial cells: changes in immune function, vascularization, and differentiation.PITX2 is involved in stress response in cultured human trabecular meshwork cells through regulation of SLC13A3.Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) integrates developmental signals for eyelid closure High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.Loss of Ezh2 promotes a midbrain-to-forebrain identity switch by direct gene derepression and Wnt-dependent regulation Disruption of eyelid and cornea morphogenesis by epithelial β-catenin gain-of-function.Identification of host proteins, Spata3 and Dkk2, interacting with Toxoplasma gondii micronemal protein MIC3.Wnt/β-catenin signaling modulates corneal epithelium stratification via inhibition of Bmp4 during mouse development Lgr4 in ocular development and glaucoma High throughput gene expression analysis identifies reliable expression markers of human corneal endothelial cells.Spdef null mice lack conjunctival goblet cells and provide a model of dry eye.FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate.Spry1 and Spry2 are necessary for eyelid closure.Expression of signaling components in embryonic eyelid epithelium.Signaling "cross-talk" is integrated by transcription factors in the development of the anterior segment in the eye.Small-molecule induction promotes corneal epithelial cell differentiation from human induced pluripotent stem cells.Foxc1 and Foxc2 in the Neural Crest Are Required for Ocular Anterior Segment Development.c-Jun, at the crossroad of the signaling network.Development of astrocytes in the vertebrate eye PITX2 and non-canonical Wnt pathway interaction in metastatic prostate cancer.

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P2860

The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development.

http://www.wikidata.org/entity/Q36663184

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2008 nî lūn-bûn

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Dianqing Wu

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Kevin I Rosenberg

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Min Qian

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P2860

Coats' disease of the retina (unilateral retinal telangiectasis) caused by somatic mutation in the NDP gene: a role for norrin in retinal angiogenesis

Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome

Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis

Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors

Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy

Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q.

The molecular basis of Rieger syndrome. Analysis of Pitx2 homeodomain protein activities

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

A mutation in the Norrie disease gene (NDP) associated with X-linked familial exudative vitreoretinopathy

Autosomal dominant iris hypoplasia is caused by a mutation in the Rieger syndrome (RIEG/PITX2) gene

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310-324

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10.1016/J.YDBIO.2008.02.030

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