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Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesisPitx2 is an upstream activator of extraocular myogenesis and survivalAP-2alpha knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesisTbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart fieldExtraocular muscle morphogenesis and gene expression are regulated by Pitx2 gene doseMyocardial Pitx2 differentially regulates the left atrial identity and ventricular asymmetric remodeling programsHuman PRKC apoptosis WT1 regulator is a novel PITX2-interacting protein that regulates PITX2 transcriptional activity in ocular cells.Shroom3 and a Pitx2-N-cadherin pathway function cooperatively to generate asymmetric cell shape changes during gut morphogenesisThe homeodomain transcription factor PITX2 is required for specifying correct cell fates and establishing angiogenic privilege in the developing corneaExpression of Pitx2 in stromal cells is required for normal hematopoiesisMutation of FOXC1 and PITX2 induces cerebral small-vessel disease.The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development.Pituitary homeobox 2, a novel member of the bicoid-related family of homeobox genes, is a potential regulator of anterior structure formation.FGF9-Pitx2-FGF10 signaling controls cecal formation in mice.Signaling "cross-talk" is integrated by transcription factors in the development of the anterior segment in the eye.Canonical Wnt/β-catenin signaling is required for maintenance but not activation of Pitx2 expression in neural crest during eye developmentPitx2 distinguishes subtypes of terminally differentiated neurons in the developing mouse neuroepithelium.Transgenic mice expressing Cre-recombinase specifically in M- or S-cone photoreceptors.Hematopoiesis following disruption of the Pitx2 homeodomain gene.Characterization of mouse orthologue of ELOVL4: genomic organization and spatial and temporal expression.Nestin-Cre mediated deletion of Pitx2 in the mouse.The Ames dwarf gene, df, is required early in pituitary ontogeny for the extinction of Rpx transcription and initiation of lineage-specific cell proliferation.PITX genes are required for cell survival and Lhx3 activation.PITX2 is required for normal development of neurons in the mouse subthalamic nucleus and midbrain.Sequential expression and redundancy of Pitx2 and Pitx3 genes during muscle development.Reduced human and murine corneal thickness in an Axenfeld-Rieger syndrome subtype.Expression of the homeobox gene Pitx2 in neural crest is required for optic stalk and ocular anterior segment development.The bicoid-related Pitx gene family in development.Fate maps of neural crest and mesoderm in the mammalian eye.
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hulumtues
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Philip Gage
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Philip Gage
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Philip Gage
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Philip Gage
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Philip Gage
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Philip Gage
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Philip Gage
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Philip Gage
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Philip Gage
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Philip Gage
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Philip Gage
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Philip Gage
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Philip Gage
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