Platelet-derived growth factor receptor can mediate tumorigenic transformation by the bovine papillomavirus E5 protein.
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Association of insulin receptor substrate 1 with simian virus 40 large T antigenMechanisms of cell transformation by papillomavirus E5 proteins.Artificial transmembrane oncoproteins smaller than the bovine papillomavirus E5 protein redefine sequence requirements for activation of the platelet-derived growth factor beta receptor.Construction and genetic selection of small transmembrane proteins that activate the human erythropoietin receptor.Bovine papillomavirus E5 protein induces oligomerization and trans-phosphorylation of the platelet-derived growth factor beta receptor.A lysine-to-arginine change found in natural alleles of the human T-cell lymphotropic/leukemia virus type 1 p12(I) protein greatly influences its stability.Endogenous human papillomavirus E6 and E7 proteins differentially regulate proliferation, senescence, and apoptosis in HeLa cervical carcinoma cellsThe E5 proteinsMultiple transmembrane amino acid requirements suggest a highly specific interaction between the bovine papillomavirus E5 oncoprotein and the platelet-derived growth factor beta receptor.Expression of platelet derived growth factor family members and the potential role of imatinib mesylate for cervical cancer.Viral miniproteinsPapillomavirus E5: the smallest oncoprotein with many functions.Mutational analysis of the interaction between the bovine papillomavirus E5 transforming protein and the endogenous beta receptor for platelet-derived growth factor in mouse C127 cells.Mutational analysis of the beta-type platelet-derived growth factor receptor defines the site of interaction with the bovine papillomavirus type 1 E5 transforming protein.E5 oncoprotein transmembrane mutants dissociate fibroblast transforming activity from 16-kilodalton protein binding and platelet-derived growth factor receptor binding and phosphorylation.The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor beta and gammac chains and affects their expression on the cell surfaceIdentification of amino acids in the transmembrane and juxtamembrane domains of the platelet-derived growth factor receptor required for productive interaction with the bovine papillomavirus E5 protein.Hydrophobic Mismatch Drives the Interaction of E5 with the Transmembrane Segment of PDGF Receptor.Ligand-independent activation of the platelet-derived growth factor beta receptor: requirements for bovine papillomavirus E5-induced mitogenic signaling.The bovine papillomavirus type 1 E5 transforming protein specifically binds and activates the beta-type receptor for the platelet-derived growth factor but not other related tyrosine kinase-containing receptors to induce cellular transformation.Specific interaction between the bovine papillomavirus E5 transforming protein and the beta receptor for platelet-derived growth factor in stably transformed and acutely transfected cellsMutation of the bovine papillomavirus E5 oncoprotein at amino acid 17 generates both high- and low-transforming variantsSimian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptorBovine papillomaviruses, papillomas and cancer in cattle.A single amino acid substitution converts a transmembrane protein activator of the platelet-derived growth factor β receptor into an inhibitor.The bovine papillomavirus E5 protein and the PDGF beta receptor: it takes two to tango.E5 oncoprotein retained in the endoplasmic reticulum/cis Golgi still induces PDGF receptor autophosphorylation but does not transform cellsCompensatory mutants of the bovine papillomavirus E5 protein and the platelet-derived growth factor β receptor reveal a complex direct transmembrane interaction.Polyomavirus large T antigen induces alterations in cytoplasmic signalling pathways involving Shc activation.Role of glutamine 17 of the bovine papillomavirus E5 protein in platelet-derived growth factor beta receptor activation and cell transformation.Failure of the bovine papillomavirus to transform mouse embryo fibroblasts with a targeted disruption of the insulin-like growth factor I receptor genes.Upregulation of swelling-activated Cl- channel sensitivity to cell volume by activation of EGF receptors in murine mammary cells.Molecular examination of the transmembrane requirements of the platelet-derived growth factor beta receptor for a productive interaction with the bovine papillomavirus E5 oncoprotein.Bovine papillomavirus E5 protein induces the formation of signal transduction complexes containing dimeric activated platelet-derived growth factor beta receptor and associated signaling proteins.Expression of epidermal growth factor and platelet-derived growth factor receptors during cervical carcinogenesis.The transmembrane domain of the E5 oncoprotein contains functionally discrete helical faces.Lack in efficacy for imatinib mesylate as second-line treatment of recurrent or metastatic cervical cancer expressing platelet-derived growth factor receptor alpha.Structural models of the bovine papillomavirus E5 protein.
P2860
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P2860
Platelet-derived growth factor receptor can mediate tumorigenic transformation by the bovine papillomavirus E5 protein.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Platelet-derived growth factor ...... ine papillomavirus E5 protein.
@ast
Platelet-derived growth factor ...... ine papillomavirus E5 protein.
@en
type
label
Platelet-derived growth factor ...... ine papillomavirus E5 protein.
@ast
Platelet-derived growth factor ...... ine papillomavirus E5 protein.
@en
prefLabel
Platelet-derived growth factor ...... ine papillomavirus E5 protein.
@ast
Platelet-derived growth factor ...... ine papillomavirus E5 protein.
@en
P2860
P356
P1476
Platelet-derived growth factor ...... ine papillomavirus E5 protein.
@en
P2093
P2860
P304
P356
10.1128/MCB.13.7.4137
P407
P577
1993-07-01T00:00:00Z