Effect of Ritonavir on (99m)Technetium-Mebrofenin Disposition in Humans: A Semi-PBPK Modeling and In Vitro Approach to Predict Transporter-Mediated DDIs
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Systems pharmacology modeling predicts delayed presentation and species differences in bile acid-mediated troglitazone hepatotoxicityAltered morphine glucuronide and bile acid disposition in patients with nonalcoholic steatohepatitisSandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury.Determination of intracellular unbound concentrations and subcellular localization of drugs in rat sandwich-cultured hepatocytes compared with liver tissue.Intracellular drug concentrations and transporters: measurement, modeling, and implications for the liver.Prediction of pharmacokinetics and drug-drug interactions when hepatic transporters are involved.Prediction of Hepatic Efflux Transporter-Mediated Drug Interactions: When Is it Optimal to Measure Intracellular Unbound Fraction of Inhibitors?Prediction of Altered Bile Acid Disposition Due to Inhibition of Multiple Transporters: An Integrated Approach Using Sandwich-Cultured Hepatocytes, Mechanistic Modeling, and Simulation.Mechanistic understanding of the nonlinear pharmacokinetics and intersubject variability of simeprevir: A PBPK-guided drug development approach.Transporter-mediated Alterations in Patients with NASH Increase Systemic and Hepatic Exposure to an OATP and MRP2 Substrate.Prediction of drug-drug interaction potential using physiologically based pharmacokinetic modeling.Influence of OATPs on Hepatic Disposition of Erlotinib Measured With Positron Emission Tomography.Technetium Tc 99m sulfur colloid phenotypic probe for the pharmacokinetics and pharmacodynamics of PEGylated liposomal doxorubicin in women with ovarian cancer.
P2860
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P2860
Effect of Ritonavir on (99m)Technetium-Mebrofenin Disposition in Humans: A Semi-PBPK Modeling and In Vitro Approach to Predict Transporter-Mediated DDIs
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Effect of Ritonavir on (99m)Te ...... dict Transporter-Mediated DDIs
@ast
Effect of Ritonavir on (99m)Te ...... dict Transporter-Mediated DDIs
@en
type
label
Effect of Ritonavir on (99m)Te ...... dict Transporter-Mediated DDIs
@ast
Effect of Ritonavir on (99m)Te ...... dict Transporter-Mediated DDIs
@en
prefLabel
Effect of Ritonavir on (99m)Te ...... dict Transporter-Mediated DDIs
@ast
Effect of Ritonavir on (99m)Te ...... dict Transporter-Mediated DDIs
@en
P2093
P2860
P356
P1476
Effect of Ritonavir on (99m)Te ...... dict Transporter-Mediated DDIs
@en
P2093
G Ghibellini
K L R Brouwer
L M Gangarosa
M Ivanovic
N D Pfeifer
W D Heizer
P2860
P356
10.1038/PSP.2012.21
P577
2013-01-02T00:00:00Z