Regulation of feedback between protein kinase A and the proteasome system worsens Huntington's disease
about
Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugatesA dynamic interface between ubiquitylation and cAMP signalingRole of protein kinase A in regulating mitochondrial function and neuronal development: implications to neurodegenerative diseasesThe 26S proteasome drives trinucleotide repeat expansionsThe roles of the RIIβ linker and N-terminal cyclic nucleotide-binding domain in determining the unique structures of the type IIβ protein kinase A: a small angle x-ray and neutron scattering study.Phosphorylation of the 19S regulatory particle ATPase subunit, Rpt6, modifies susceptibility to proteotoxic stress and protein aggregation.4-Phenylbutyrate attenuates the ER stress response and cyclic AMP accumulation in DYT1 dystonia cell models.Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling.Imaging the Insertion of Superecliptic pHluorin-Labeled Dopamine D2 Receptor Using Total Internal Reflection Fluorescence Microscopy.A striatal-enriched intronic GPCR modulates huntingtin levels and toxicitycAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins.Reversible phosphorylation of the 26S proteasome.Nuclear inclusion bodies of mutant and wild-type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation.Elucidating the role of the A2A adenosine receptor in neurodegeneration using neurons derived from Huntington's disease iPSCs.PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model.Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease.Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain.Targeting the 26S Proteasome To Protect Against Proteotoxic Diseases.Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology.Protein Modifications with Ubiquitin as Response to Cerebral Ischemia-Reperfusion Injury.Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse.The Role of Adenosine Tone and Adenosine Receptors in Huntington's Disease
P2860
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P2860
Regulation of feedback between protein kinase A and the proteasome system worsens Huntington's disease
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
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2012年论文
@zh-cn
name
Regulation of feedback between ...... m worsens Huntington's disease
@ast
Regulation of feedback between ...... m worsens Huntington's disease
@en
type
label
Regulation of feedback between ...... m worsens Huntington's disease
@ast
Regulation of feedback between ...... m worsens Huntington's disease
@en
prefLabel
Regulation of feedback between ...... m worsens Huntington's disease
@ast
Regulation of feedback between ...... m worsens Huntington's disease
@en
P2093
P2860
P356
P1476
Regulation of feedback between ...... m worsens Huntington's disease
@en
P2093
Chih-Yeh Chen
Hsing-Lin Lai
Hui-Mei Chen
Jiun-Tsai Lin
Mi-Hua Tao
Wei-Cheng Chang
Yijuang Chern
P2860
P304
P356
10.1128/MCB.01434-12
P407
P577
2012-12-28T00:00:00Z