Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease
about
Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington diseaseRole of cerebral cortex in the neuropathology of Huntington's diseaseMouse models of polyglutamine diseases: review and data table. Part IPluripotent stem cells models for Huntington's disease: prospects and challengesDisrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatumOnset and progression of behavioral and molecular phenotypes in a novel congenic R6/2 line exhibiting intergenerational CAG repeat stability.Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington diseaseMouse models of Huntington's disease and methodological considerations for therapeutic trials.Neurexophilin 3 is highly localized in cortical and cerebellar regions and is functionally important for sensorimotor gating and motor coordinationFunctional imaging in Huntington's disease.Progressive synaptic pathology of motor cortical neurons in a BAC transgenic mouse model of Huntington's disease.Complexity and heterogeneity: what drives the ever-changing brain in Huntington's disease?Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease.Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysisHuntingtin localisation studies - a technical review.Differential vulnerability of neurons in Huntington's disease: the role of cell type-specific features.Transgenic animal models of neurodegeneration based on human genetic studies.Functional Changes in Neocortical Activity in Huntington's Disease Model Mice: An in vivo Intracellular Study.Impaired alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking and function by mutant huntingtin.Conditional BDNF release under pathological conditions improves Huntington's disease pathology by delaying neuronal dysfunction.Altered excitatory and inhibitory inputs to striatal medium-sized spiny neurons and cortical pyramidal neurons in the Q175 mouse model of Huntington's disease.An anticholinergic reverses motor control and corticostriatal LTD deficits in Dyt1 ΔGAG knock-in mice.Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's diseaseCAG repeat lengths > or =335 attenuate the phenotype in the R6/2 Huntington's disease transgenic mouse.Striatal atrophy and dendritic alterations in a knock-in mouse model of Huntington's disease.Glutamate receptor abnormalities in the YAC128 transgenic mouse model of Huntington's disease.Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits.A role for Kalirin-7 in corticostriatal synaptic dysfunction in Huntington's diseaseSuppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasmElevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington's disease.The corticostriatal pathway in Huntington's disease.Multiple pathways contribute to the pathogenesis of Huntington disease.Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouseCharacterization of forebrain neurons derived from late-onset Huntington's disease human embryonic stem cell lines.Regulation of feedback between protein kinase A and the proteasome system worsens Huntington's diseaseDrug targeting of dysregulated transcription in Huntington's diseaseFull length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease.Multiple sources of striatal inhibition are differentially affected in Huntington's disease mouse models.Dysregulated information processing by medium spiny neurons in striatum of freely behaving mouse models of Huntington's disease.Altered information processing in the prefrontal cortex of Huntington's disease mouse models.
P2860
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P2860
Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease
description
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2001
@ast
im Dezember 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/12/01)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/12/01)
@nl
наукова стаття, опублікована в грудні 2001
@uk
مقالة علمية (نشرت في ديسمبر 2001)
@ar
name
Changes in cortical and striat ...... model of Huntington's disease
@ast
Changes in cortical and striat ...... model of Huntington's disease
@en
Changes in cortical and striat ...... model of Huntington's disease
@nl
type
label
Changes in cortical and striat ...... model of Huntington's disease
@ast
Changes in cortical and striat ...... model of Huntington's disease
@en
Changes in cortical and striat ...... model of Huntington's disease
@nl
prefLabel
Changes in cortical and striat ...... model of Huntington's disease
@ast
Changes in cortical and striat ...... model of Huntington's disease
@en
Changes in cortical and striat ...... model of Huntington's disease
@nl
P2093
P921
P3181
P1476
Changes in cortical and striat ...... model of Huntington's disease
@en
P2093
B A Cadigan
C McIntyre
C R Calvert
G A Laforet
G J Klapstein
P304
P3181
P356
10.1523/JNEUROSCI.21-23-09112.2001
P407
P577
2001-12-01T00:00:00Z