Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells
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Autocrine PDGFR signaling promotes mammary cancer metastasisIn situ visualization of intratumor growth factor signaling: immunohistochemical localization of activated ERK/MAP kinase in glial neoplasms.Phase II study of Gleevec plus hydroxyurea in adults with progressive or recurrent low-grade glioma.Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomasDominant negative PDGF-C inhibits growth of Ewing family tumor cell lines.RETRACTED: Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class.Neural development and the ontogeny of central nervous system tumors.Cancer gene therapy.Expression of the somatostatin gene in human astrocytoma cell lines.Post-transcriptional regulation of PDGFα-receptor in O-2A progenitor cells.FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells.Development of novel targeted therapies in the treatment of malignant glioma.Functional tyrosine kinase inhibitor profiling: a generally applicable method points to a novel role of platelet-derived growth factor receptor-beta in tuberous sclerosis.Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma.Tyrosine kinases in disease: overview of kinase inhibitors as therapeutic agents and current drugs in clinical trials.An antagonistic vascular endothelial growth factor (VEGF) variant inhibits VEGF-stimulated receptor autophosphorylation and proliferation of human endothelial cellsRepression of platelet-derived growth factor beta-receptor expression by mitogenic growth factors and transforming oncogenes in murine 3T3 fibroblasts.Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation.Inhibition of platelet-derived growth factor signalling induces autophagy in malignant glioma cellsAdenoviral gene transfer of PDGF downregulates gas gene product PDGFalphaR and prolongs ERK and Akt/PKB activation.Inhibition of receptor signaling and of glioblastoma-derived tumor growth by a novel PDGFRβ aptamer.Autocrine PDGF stimulation in malignancies.Necrosis is not induced by gadolinium neutron capture in glioblastoma multiforme cells.Growth factor receptors signaling in glioblastoma cells: therapeutic implications.Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells.Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins.NF-kappaB controls growth of glioblastomas/astrocytomas.Increased sensitivity to the platelet-derived growth factor (PDGF) receptor inhibitor STI571 in chemoresistant glioma cells is associated with enhanced PDGF-BB-mediated signaling and STI571-induced Akt inactivation.Signal transduction interception as a novel approach to disease management.Effect of sustained gene delivery of platelet-derived growth factor or its antagonist (PDGF-1308) on tissue-engineered cementum.Mouse glioma gene expression profiling identifies novel human glioma-associated genes.Platelet-derived growth factor-dependent cellular transformation requires either phospholipase Cgamma or phosphatidylinositol 3 kinase.Production of cell-associated PDGF-AA by a human sarcoma cell line: evidence for a latent autocrine effect.Transcriptional regulation of the SIS/PDGF-B gene in human osteosarcoma cells by the Sp family of transcription factors.Loop III region of platelet-derived growth factor (PDGF) B-chain mediates binding to PDGF receptors and heparin.Engineering of tooth-supporting structures by delivery of PDGF gene therapy vectors.Gene transfer and expression of platelet-derived growth factors modulate periodontal cellular activity.Expression of platelet derived growth factor and platelet derived growth factor receptor mRNA in a glioblastoma from a patient with Li-Fraumeni syndrome.Human breast cancer growth inhibited in vivo by a dominant negative pleiotrophin mutant.Compartmentalization of autocrine signal transduction pathways in Sis-transformed NIH 3T3 cells.
P2860
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P2860
Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Dominant-negative mutants of p ...... ype of human astrocytoma cells
@en
type
label
Dominant-negative mutants of p ...... ype of human astrocytoma cells
@en
prefLabel
Dominant-negative mutants of p ...... ype of human astrocytoma cells
@en
P2093
P2860
P356
P1476
Dominant-negative mutants of p ...... ype of human astrocytoma cells
@en
P2093
P2860
P304
P356
10.1128/MCB.13.12.7203
P407
P577
1993-12-01T00:00:00Z