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Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus MethyltransferaseSurface Proteoglycans as Mediators in Bacterial Pathogens InfectionsThe Regulation of Steroid Action by Sulfation and DesulfationPathophysiology of heparan sulphate: many diseases, few drugsHeparan sulfate in skeletal development, growth, and pathology: the case of hereditary multiple exostosesMonocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia.Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1.The Surprising Role of Amyloid Fibrils in HIV InfectionAminoquinoline surfen inhibits the action of SEVI (semen-derived enhancer of viral infection).A chemical biology approach demonstrates G protein βγ subunits are sufficient to mediate directional neutrophil chemotaxis.A peptide found by phage display discriminates a specific structure of a trisaccharide in heparin.Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI.Specific sides to multifaceted glycosaminoglycans are observed in embryonic development.Heparan sulfate regulates VEGF165- and VEGF121-mediated vascular hyperpermeability.A peptide inhibitor of cytomegalovirus infection from human hemofiltrateHeparanase stimulates chondrogenesis and is up-regulated in human ectopic cartilage: a mechanism possibly involved in hereditary multiple exostoses.The C-terminal fragment of axon guidance molecule Slit3 binds heparin and neutralizes heparin's anticoagulant activity.Proteoglycans in host-pathogen interactions: molecular mechanisms and therapeutic implicationsN-sulfation of heparan sulfate regulates early branching events in the developing mammary gland.Linear polyalkylamines as fingerprinting agents in capillary electrophoresis of low-molecular-weight heparins and glycosaminoglycans.A Haploid Genetic Screen Identifies Heparan Sulfate Proteoglycans Supporting Rift Valley Fever Virus InfectionInhibition of polyphosphate as a novel strategy for preventing thrombosis and inflammation.Development of novel entry inhibitors targeting emerging viruses.Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses.Heparan sulfate proteoglycans are receptors for the cell-surface trafficking and biological activity of transglutaminase-2.Cyclic tensile strain triggers a sequence of autocrine and paracrine signaling to regulate angiogenic sprouting in human vascular cells.Small molecule antagonists of cell-surface heparan sulfate and heparin-protein interactions.Heparan sulfates mediate the interaction between platelet endothelial cell adhesion molecule-1 (PECAM-1) and the Gαq/11 subunits of heterotrimeric G proteins.Targeting tumor angiogenesis with TSP-1-based compounds: rational design of antiangiogenic mimetics of endogenous inhibitorsA spoonful of sugar makes the melanoma go: the role of heparan sulfate proteoglycans in melanoma metastasis.Glycosaminoglycans in infectious disease.Heparin sensing and binding - taking supramolecular chemistry towards clinical applications.Heparan sulfate in angiogenesis: a target for therapy.Restoring the glycosaminoglycans layer in recurrent cystitis: experimental and clinical foundations.Glycosaminoglycan and DNA Binding Induced Intra- and Intermolecular Exciton Coupling of the bis-4-Aminoquinoline Surfen.Hereditary Multiple Exostoses: New Insights into Pathogenesis, Clinical Complications, and Potential Treatments.Surfen is a broad-spectrum calcium channel inhibitor with analgesic properties in mouse models of acute and chronic inflammatory pain.Leveraging growth factor induced macropinocytosis for targeted treatment of lung cancer.Cell entry mechanisms of HSV: what we have learned in recent years.Interplay between transglutaminases and heparan sulphate in progressive renal scarring.
P2860
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P2860
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Surfen, a small molecule antagonist of heparan sulfate
@en
type
label
Surfen, a small molecule antagonist of heparan sulfate
@en
prefLabel
Surfen, a small molecule antagonist of heparan sulfate
@en
P2093
P2860
P356
P1476
Surfen, a small molecule antagonist of heparan sulfate
@en
P2093
Brett E Crawford
Charles A Glass
David P Ditto
Jeffrey D Esko
Jillian R Brown
Lianchun Wang
Manuela Schuksz
Mark M Fuster
Roger Lawrence
Yitzhak Tor
P2860
P304
13075-13080
P356
10.1073/PNAS.0805862105
P407
P577
2008-08-25T00:00:00Z