Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration.
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From foe to friend: using animal toxins to investigate ion channel functionAnalysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV ( -TRTX-Hh2a)Evaluation of recombinant monoclonal antibody SVmab1 binding to Na V1.7 target sequences and block of human Na V1.7 currentsSynergetic action of domain II and IV underlies persistent current generation in Nav1.3 as revealed by a tarantula toxin.Insect-Active Toxins with Promiscuous Pharmacology from the African Theraphosid Spider Monocentropus balfouriTargeting voltage sensors in sodium channels with spider toxins.Use of venom peptides to probe ion channel structure and function.Functional expression of spider neurotoxic peptide huwentoxin-I in E. coli.Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins.Neurotoxins and their binding areas on voltage-gated sodium channels.The tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation.Native pyroglutamation of huwentoxin-IV: a post-translational modification that increases the trapping ability to the sodium channel.Structure of membrane-active toxin from crab spider Heriaeus melloteei suggests parallel evolution of sodium channel gating modifiers in Araneomorphae and MygalomorphaeComputational approaches for designing potent and selective analogs of peptide toxins as novel therapeutics.Recombinant expression and in vitro characterisation of active Huwentoxin-IV.Screening for voltage-gated sodium channel interacting peptides.Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IVStructure-function map of the receptor site for β-scorpion toxins in domain II of voltage-gated sodium channelsSeven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach.Sensitivity of cloned muscle, heart and neuronal voltage-gated sodium channels to block by polyamines: a possible basis for modulation of excitability in vivo.Biophysical properties of Na(v) 1.8/Na(v) 1.2 chimeras and inhibition by µO-conotoxin MrVIB.The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8.Structure and function of hainantoxin-III, a selective antagonist of neuronal tetrodotoxin-sensitive voltage-gated sodium channels isolated from the Chinese bird spider Ornithoctonus hainana.Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain.CRMP2 protein SUMOylation modulates NaV1.7 channel trafficking.Molecular basis of the interaction between gating modifier spider toxins and the voltage sensor of voltage-gated ion channels.A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ.Sodium channel blockers for the treatment of neuropathic pain.Subtype-selective targeting of voltage-gated sodium channels.Furanocoumarins are a novel class of modulators for the transient receptor potential vanilloid type 1 (TRPV1) channel.Isoform-selective voltage-gated Na(+) channel modulators as next-generation analgesics.Advances in targeting voltage-gated sodium channels with small molecules.The insecticidal potential of venom peptides.Animal toxins influence voltage-gated sodium channel function.Biophysics, pathophysiology, and pharmacology of ion channel gating pores.Venom: the sharp end of pain therapeuticsLengths of the C-Terminus and Interconnecting Loops Impact Stability of Spider-Derived Gating Modifier Toxins.The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Nav1.7.Electrophysiological Studies of Voltage-Gated Sodium Channels Using QPatch HT, an Automated Patch-Clamp System.
P2860
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P2860
Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Tarantula huwentoxin-IV inhibi ...... r in the closed configuration.
@en
type
label
Tarantula huwentoxin-IV inhibi ...... r in the closed configuration.
@en
prefLabel
Tarantula huwentoxin-IV inhibi ...... r in the closed configuration.
@en
P2093
P2860
P356
P1476
Tarantula huwentoxin-IV inhibi ...... r in the closed configuration.
@en
P2093
Edward Moczydlowski
Jon-Paul Bingham
Songping Liang
Theodore R Cummins
Weiguo Zhu
Yucheng Xiao
P2860
P304
27300-27313
P356
10.1074/JBC.M708447200
P407
P577
2008-07-14T00:00:00Z