Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo.
about
Deficient spindle assembly checkpoint in multiple myelomaProinvasion metastasis drivers in early-stage melanoma are oncogenes.MTBP plays a crucial role in mitotic progression and chromosome segregationChromosomal instability and cancer: a complex relationship with therapeutic potentialMAPping the Ndc80 loop in cancer: A possible link between Ndc80/Hec1 overproduction and cancer formationAurora B hyperactivation by Bub1 overexpression promotes chromosome missegregationTranscriptional control of mitosis: deregulation and cancerAlp7/TACC recruits kinesin-8-PP1 to the Ndc80 kinetochore protein for timely mitotic progression and chromosome movement.Transgenic, inducible RNAi in megakaryocytes and platelets in mice.Effect of NDC80 in human hepatocellular carcinomaKinetochore genes are coordinately up-regulated in human tumors as part of a FoxM1-related cell division program.Abnormal kinetochore-generated pulling forces from expressing a N-terminally modified Hec1.Mitotic chromosomal instability and cancer: mouse modelling of the human disease.Microcell-mediated chromosome transfer identifies EPB41L3 as a functional suppressor of epithelial ovarian cancers.Chromosome missegregation causes colon cancer by APC loss of heterozygosity.Macrophages facilitate coal tar pitch extract-induced tumorigenic transformation of human bronchial epithelial cells mediated by NF-κB.Tumor environmental factors glucose deprivation and lactic acidosis induce mitotic chromosomal instability--an implication in aneuploid human tumors.Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivationRole of NEK2A in human cancer and its therapeutic potentials.Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint.Chromosomal instability as a prognostic marker in cervical cancer.Correction of microtubule-kinetochore attachment errors: mechanisms and role in tumor suppression.Overexpression of NDC80 is correlated with prognosis of pancreatic cancer and regulates cell proliferation.Losing balance: the origin and impact of aneuploidy in cancerCoiled-coil networking shapes cell molecular machineryCo-expression of mitosis-regulating genes contributes to malignant progression and prognosis in oligodendrogliomas.Aneuploidy in health, disease, and aging.Upregulation of colonic and hepatic tumor overexpressed gene is significantly associated with the unfavorable prognosis marker of human hepatocellular carcinoma.Hec1-dependent cyclin B2 stabilization regulates the G2-M transition and early prometaphase in mouse oocytesCancer karyotypes: survival of the fittest2n or not 2n: Aneuploidy, polyploidy and chromosomal instability in primary and tumor cells.Chromosomes and cancer cells.Mechanisms of chromosomal instability.Hec1 contributes to mitotic centrosomal microtubule growth for proper spindle assembly through interaction with Hice1.Characterization of the biological activity of a potent small molecule Hec1 inhibitor TAI-1.An RNAi-based screen reveals PLK1, CDK1 and NDC80 as potential therapeutic targets in malignant pleural mesothelioma.Coordinated regulation of p31(Comet) and Mad2 expression is required for cellular proliferationBoveri revisited: chromosomal instability, aneuploidy and tumorigenesisNew insights into the troubles of aneuploidyThe mitotic tensegrity guardian tau protects mammary epithelia from katanin-like1-induced aneuploidy.
P2860
Q21560908-435DE9D0-B451-46D8-95AC-60024B02FCDAQ24312173-7ED41401-DE3B-4D61-9B95-EF7276D6B579Q24338557-4DFC88D0-D225-4D5C-A739-6A9C9C84E39EQ24608609-301DEAD9-90C0-4532-9226-376B659450FCQ26991530-EB3E3B82-B8AF-49A1-8131-424819322EADQ26995347-EBA3515E-ADDD-4C48-AA28-9CAE2CE107A4Q28082114-DB791AE2-CF9A-4D29-B069-15D87E54D21AQ30615589-6FD56356-D67F-4C1D-94B6-EC774C68DCD5Q33393167-6C0AFAD6-25DE-49C2-AEF5-EBB5D1E7202DQ33740474-3BDBB619-CD5D-4CD5-8B81-13E240B60000Q33811933-05B1140B-B05F-423B-814F-08BBF86309B9Q33813043-F68BE299-061C-4022-BDEC-161DAD3469C0Q33926467-8FF6A2C6-F13D-4F83-A9F9-10ED889CE87AQ34009859-19CDD2CC-2F2C-4FFB-B83E-B6179570C318Q34239366-119F83B8-0912-4C6D-85A0-79E50BD7F923Q34507403-680815CD-BE67-4774-825B-18A06846BDB0Q34722734-CAB15016-ED60-426D-8D7D-AD547264715CQ35047487-1027D2D0-47B6-4D96-A4E1-53A1BBDC58DDQ35090475-306138E3-E3C4-48BE-8B4C-B2FA608B391AQ35241521-57F9BA81-05B7-4752-B7C5-B7193674B955Q35610374-C5D7DF78-A0B6-40EF-A328-CA82691F9276Q35632434-DCF4697C-34F8-4964-908A-968CB7B7ECB5Q35835237-A4DC5431-C88C-44D4-911F-3CD3F8241C30Q36008297-F999D2A0-9C4F-4A6D-AA01-528FF295C2E1Q36284528-C440DE72-32D5-4929-B472-E78351851144Q36546013-C7A62606-F0C4-4E5D-872C-5AB72DBA7C9CQ36732750-6282EF09-7EFE-47EE-9BA8-E508083DB7A3Q36853891-1A584D98-4DE1-48F4-A02B-F8B39185276DQ36860059-C361BB02-FAB0-4AA1-8F57-1961FF968E1AQ36909580-A21EFBE6-BA71-41B5-A180-3C70FC92E8A9Q37078688-41AE01DA-3205-4C2D-87A6-F60B2BD3870CQ37165291-4B668D12-7D78-450F-892E-52EA0B4CCEECQ37193068-806C7C72-DA75-4B69-AA1F-625D83B1758FQ37420449-BC5DFDEF-EEEA-45FD-A6C7-283C1086FDF4Q37493920-308007A1-0671-4053-AA95-6E3643711104Q37507415-AA0FAC19-A932-45C6-B7A4-EA8AA01A385DQ37525854-A139E86F-E07E-4F30-BA6C-D7BCBF7D0AEEQ37527786-B78B302F-E384-48A9-819A-26DD63D341E8Q37574324-74F74A0D-6171-4260-8210-5DDC70599AB0Q37619817-E9E2FC65-B64B-492A-AF9D-59F4B5CE834D
P2860
Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Hec1 overexpression hyperactiv ...... duces tumor formation in vivo.
@en
type
label
Hec1 overexpression hyperactiv ...... duces tumor formation in vivo.
@en
prefLabel
Hec1 overexpression hyperactiv ...... duces tumor formation in vivo.
@en
P2093
P2860
P356
P1476
Hec1 overexpression hyperactiv ...... duces tumor formation in vivo.
@en
P2093
Elena Diaz-Rodríguez
Juan-Manuel Schvartzman
Robert Benezra
Rocio Sotillo
P2860
P304
16719-16724
P356
10.1073/PNAS.0803504105
P407
P577
2008-10-21T00:00:00Z