Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins.
about
Modulating splicing with small molecular inhibitors of the spliceosomeThe Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates SplicingManagement of lower-risk myelodysplastic syndromes without del5q: current approach and future trends.Established and emerging targeted therapies in the myelodysplastic syndromes.How do messenger RNA splicing alterations drive myelodysplasia?The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemiaTargeting Splicing in the Treatment of Myelodysplastic Syndromes and Other Myeloid Neoplasms.Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival.Alternate splicing of transcripts shape macrophage response to Mycobacterium tuberculosis infection.Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome.Splice Variants of the RTK Family: Their Role in Tumour Progression and Response to Targeted Therapy.New drug discovery approaches targeting recurrent mutations in chronic lymphocytic leukemia.CMML: Clinical and molecular aspects.Turning the tide in myelodysplastic/myeloproliferative neoplasms.The mutational oncoprint of recurrent cytogenetic abnormalities in adult patients with de novo acute myeloid leukemia.Clinical Implications of Genetic Mutations in Myelodysplastic Syndrome.Splicing-factor alterations in cancers.Therapeutic targeting of splicing in cancer.Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.Splicing factor gene mutations in hematologic malignancies.RNA splicing during terminal erythropoiesis.Modulation of aberrant splicing in human RNA diseases by chemical compounds.Splicing Factor Mutations in Myelodysplasias: Insights from Spliceosome Structures.RNA editing-dependent epitranscriptome diversity in cancer stem cells.The role of RNA alternative splicing in regulating cancer metabolism.Chronic lymphocytic leukaemia genomics and the precision medicine era.Splicing factor mutations in MDS RARS and MDS/MPN-RS-T.Modeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities.Phosphoproteomics reveals that glycogen synthase kinase-3 phosphorylates multiple splicing factors and is associated with alternative splicing.The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype.PRPF8 is important for BRCA1-mediated homologous recombination.Molecular basis of differential 3' splice site sensitivity to anti-tumor drugs targeting U2 snRNP.Circular RNAs of the nucleophosmin (NPM1) gene in acute myeloid leukemia.Precision Medicine in Children and Young Adults with Hematologic Malignancies and Blood Disorders: The Columbia University Experience.Exploiting differential RNA splicing patterns: a potential new group of therapeutic targets in cancer.Atypical chronic myeloid leukemia: a rare entity with management challenges.Clinical features and biological implications of different U2AF1 mutation types in myelodysplastic syndromes.Predicting effective pro-apoptotic anti-leukaemic drug combinations using co-operative dynamic BH3 profiling.Molecular Pathways: Understanding and Targeting Mutant Spliceosomal Proteins.Therapeutic Applications of Targeted Alternative Splicing to Cancer Treatment.
P2860
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P2860
Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Modulation of splicing catalys ...... ncoding spliceosomal proteins.
@en
type
label
Modulation of splicing catalys ...... ncoding spliceosomal proteins.
@en
prefLabel
Modulation of splicing catalys ...... ncoding spliceosomal proteins.
@en
P2093
P2860
P50
P356
P1433
P1476
Modulation of splicing catalys ...... ncoding spliceosomal proteins.
@en
P2093
Alessandro Pastore
James Palacino
Jean-Baptiste Micol
Justin Taylor
Michael Thomas
Omar Abdel-Wahab
Peter G Smith
Scott A Armstrong
Silvia Buonamici
P2860
P2888
P304
P356
10.1038/NM.4097
P407
P50
P577
2016-05-02T00:00:00Z