Modeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities.

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Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1.Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene

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Modeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities.

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2016 nî lūn-bûn

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2016年の論文

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2016年論文

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2016年論文

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2016年論文

@zh-hk

2016年論文

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2016年論文

@zh-tw

2016年论文

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2016年论文

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2016年论文

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name

Modeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities.

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Modeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities.

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Modeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities.

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P1476

Modeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities.

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Daichi Inoue

http://www.w3.org/2001/XMLSchema#string

Omar Abdel-Wahab

http://www.w3.org/2001/XMLSchema#string

P2860

Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1

SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition.

Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo.

SRSF2 Is Essential for Hematopoiesis, and Its Myelodysplastic Syndrome-Related Mutations Dysregulate Alternative Pre-mRNA Splicing.

SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes.

Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins.

SF3B1 association with chromatin determines splicing outcomes.

Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation.

Haploinsufficiency of Sf3b1 leads to compromised stem cell function but not to myelodysplasia.

Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia.

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scholarly article

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10.1016/J.CCELL.2016.08.013

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2016-09-01T00:00:00Z

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27622329

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Modeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities.

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P2860

P2860

Modeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities.

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P1433

P1476

P2093

P2860

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P356

P433

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P577

P698

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P356

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P1476

P2093

P2860

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P356

P433

P478

P577

P698

P932