Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase.
about
GRK2: multiple roles beyond G protein-coupled receptor desensitizationSonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothenedMechanism and evolution of cytosolic Hedgehog signal transductionOverlapping and opposing functions of G protein-coupled receptor kinase 2 (GRK2) and GRK5 during heart development.Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2.Clinical implications of hedgehog signaling pathway inhibitorsGrowth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signalingβ-Arrestin-mediated receptor trafficking and signal transductionRegulation of smoothened by Drosophila G-protein-coupled receptor kinases.Arrestin development: emerging roles for beta-arrestins in developmental signaling pathwaysG protein-coupled receptor kinases: more than just kinases and not only for GPCRsThe Hedgehog pathway: role in cell differentiation, polarity and proliferationDynamic landscape of tandem 3' UTRs during zebrafish developmentInhibition of G-protein-coupled receptor kinase 2 (GRK2) triggers the growth-promoting mitogen-activated protein kinase (MAPK) pathway.Smoothened determines β-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary ciliumThe relationship between sonic Hedgehog signaling, cilia, and neural tube defectsTargeting hedgehog signaling in cancer: research and clinical developments.Kinase activity-independent regulation of cyclin pathway by GRK2 is essential for zebrafish early development.Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2GRK6 regulates ROS response and maintains hematopoietic stem cell self-renewalG Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 AxisActivation of the hedgehog-signaling pathway in human cancer and the clinical implications.An essential role for Grk2 in Hedgehog signalling downstream of Smoothened.Primary cilia and graded Sonic Hedgehog signaling.The emerging roles of phosphatases in Hedgehog pathway.G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in DrosophilaGrk5l controls heart development by limiting mTOR signaling during symmetry breaking.G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog.CSNK1A1 binds SMO dimerADRBK1 binds phosphorylated SMO dimerADRBK1 phosphorylates SMO dimerThe complexities of G-protein-coupled receptor kinase function in Hedgehog signaling.
P2860
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P2860
Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Smoothened signaling in verteb ...... otein-coupled receptor kinase.
@en
type
label
Smoothened signaling in verteb ...... otein-coupled receptor kinase.
@en
prefLabel
Smoothened signaling in verteb ...... otein-coupled receptor kinase.
@en
P2093
P2860
P356
P1476
Smoothened signaling in verteb ...... otein-coupled receptor kinase.
@en
P2093
Alison R Meloni
Alyson W MacInnes
Gregory B Fralish
Lawrence S Barak
Marc G Caron
Melanie Philipp
P2860
P304
P356
10.1091/MBC.E08-05-0448
P577
2008-09-24T00:00:00Z