Disposition of flavonoids via enteric recycling: determination of the UDP-glucuronosyltransferase isoforms responsible for the metabolism of flavonoids in intact Caco-2 TC7 cells using siRNA.
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Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomesRevolving door action of breast cancer resistance protein (BCRP) facilitates or controls the efflux of flavone glucuronides from UGT1A9-overexpressing HeLa cells.The kinetic basis for age-associated changes in quercetin and genistein glucuronidation by rat liver microsomes.Use of isoform-specific UGT metabolism to determine and describe rates and profiles of glucuronidation of wogonin and oroxylin A by human liver and intestinal microsomes.Structure and concentration changes affect characterization of UGT isoform-specific metabolism of isoflavones.Triple Recycling Processes Impact Systemic and Local Bioavailability of Orally Administered Flavonoids.UDP-glucuronosyltransferase (UGT) 1A9-overexpressing HeLa cells is an appropriate tool to delineate the kinetic interplay between breast cancer resistance protein (BRCP) and UGT and to rapidly identify the glucuronide substrates of BCRP.Inhibition of genistein glucuronidation by bisphenol A in human and rat liver microsomesIdentification of the position of mono-O-glucuronide of flavones and flavonols by analyzing shift in online UV spectrum (lambdamax) generated from an online diode array detectorFirst-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics.Systematic studies of sulfation and glucuronidation of 12 flavonoids in the mouse liver S9 fraction reveal both unique and shared positional preferences.Reductive metabolism of oxymatrine is catalyzed by microsomal CYP3A4.Intestinal absorption of aloin, aloe-emodin, and aloesin; A comparative study using two in vitro absorption models.Structure-activity relationships of the glucuronidation of flavonoids by human glucuronosyltransferases.Production of human phase 1 and 2 metabolites by whole-cell biotransformation with recombinant microbes.Delivering flavonoids into solid tumors using nanotechnologies.Evaluation of UGT protein interactions in human hepatocytes: effect of siRNA down regulation of UGT1A9 and UGT2B7 on propofol glucuronidation in human hepatocytes.Uridine diphosphate glucuronosyltransferase isoform-dependent regiospecificity of glucuronidation of flavonoids.Effect of edible oils on quercetin, kaempferol and galangin transport and conjugation in the intestinal Caco-2/HT29-MTX co-culture model
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P2860
Disposition of flavonoids via enteric recycling: determination of the UDP-glucuronosyltransferase isoforms responsible for the metabolism of flavonoids in intact Caco-2 TC7 cells using siRNA.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 10 October 2007
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Disposition of flavonoids via ...... Caco-2 TC7 cells using siRNA.
@en
Disposition of flavonoids via ...... Caco-2 TC7 cells using siRNA.
@nl
type
label
Disposition of flavonoids via ...... Caco-2 TC7 cells using siRNA.
@en
Disposition of flavonoids via ...... Caco-2 TC7 cells using siRNA.
@nl
prefLabel
Disposition of flavonoids via ...... Caco-2 TC7 cells using siRNA.
@en
Disposition of flavonoids via ...... Caco-2 TC7 cells using siRNA.
@nl
P2093
P2860
P356
P1476
Disposition of flavonoids via ...... Caco-2 TC7 cells using siRNA.
@en
P2093
P2860
P304
P356
10.1021/MP0601190
P407
P577
2007-10-10T00:00:00Z