Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy. - sprookjes - yvandenbroek - TriplyDB

Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy.

Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy.

http://www.wikidata.org/entity/Q37147158

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RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention Muscleblind-like 2-mediated alternative splicing in the developing brain and dysregulation in myotonic dystrophy Muscle wasting in myotonic dystrophies: a model of premature aging Identification of variants in MBNL1 in patients with a myotonic dystrophy-like phenotype Deregulated microRNAs in myotonic dystrophy type 2 CUGBP1 overexpression in mouse skeletal muscle reproduces features of myotonic dystrophy type 1.Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans.Autoregulation of MBNL1 function by exon 1 exclusion from MBNL1 transcript.Myotonic dystrophies 1 and 2: complex diseases with complex mechanisms.Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion Overexpression of microRNA-206 in the skeletal muscle from myotonic dystrophy type 1 patients.RBFOX1 cooperates with MBNL1 to control splicing in muscle, including events altered in myotonic dystrophy type 1 MBNL proteins and their target RNAs, interaction and splicing regulation.Targeting nuclear RNA for in vivo correction of myotonic dystrophy Smaug/SAMD4A restores translational activity of CUGBP1 and suppresses CUG-induced myopathy.Analysis of exonic regions involved in nuclear localization, splicing activity, and dimerization of Muscleblind-like-1 isoforms Quantifying cancer absolute risk and cancer mortality in the presence of competing events after a myotonic dystrophy diagnosis.Dissecting domains necessary for activation and repression of splicing by Muscleblind-like protein 1 Two enhancers control transcription of Drosophila muscleblind in the embryonic somatic musculature and in the central nervous system.Genome wide identification of aberrant alternative splicing events in myotonic dystrophy type 2.Conserved RNA-binding proteins required for dendrite morphogenesis in Caenorhabditis elegans sensory neurons.Repeat-associated non-AUG translation and its impact in neurodegenerative disease.Association between NKX2-5 rs29784 and infantile hypertrophic pyloric stenosis in Chinese Han population.Cerebral and muscle MRI abnormalities in myotonic dystrophy.Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins.Cooperation meets competition in microRNA-mediated DMPK transcript regulation.Sarcolipin deletion exacerbates soleus muscle atrophy and weakness in phospholamban overexpressing mice.Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model.Alternative splicing and muscular dystrophy.Myotonic dystrophy CTG expansion affects synaptic vesicle proteins, neurotransmission and mouse behaviour.Neurodegeneration the RNA way RNA interference targeting CUG repeats in a mouse model of myotonic dystrophy.CELFish ways to modulate mRNA decay.Progressive impairment of muscle regeneration in muscleblind-like 3 isoform knockout mice.Molecular mechanisms of muscle atrophy in myotonic dystrophies.Conservation of context-dependent splicing activity in distant Muscleblind homologs Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration.Myotonic dystrophy mouse models: towards rational therapy development.Transcriptional changes and developmental abnormalities in a zebrafish model of myotonic dystrophy type 1.Altered expression and splicing of Ca(2+) metabolism genes in myotonic dystrophies DM1 and DM2.

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Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy.

http://www.wikidata.org/entity/Q37147158

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 17 February 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy.

@en

Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy.

@nl

type

label

Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy.

@en

Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy.

@nl

prefLabel

Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy.

@en

Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy.

@nl

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Human Molecular Genetics

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Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy.

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Charles A Thornton

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Jason R O'Rourke

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Krzysztof Sobczak

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Maurice S Swanson

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Robert J Osborne

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Stephen Welle

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Xiaoyan Lin

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P2860

Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy

Muscleblind proteins regulate alternative splicing

Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing

Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Molecular basis for impaired muscle differentiation in myotonic dystrophy

Significance analysis of microarrays applied to the ionizing radiation response

Identifying biological themes within lists of genes with EASE

RNA-dependent integrin alpha3 protein localization regulated by the Muscleblind-like protein MLP1

Ablation of sarcolipin enhances sarcoplasmic reticulum calcium transport and atrial contractility

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1471-1481

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scholarly article

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10.1093/HMG/DDP058

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8

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18

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19223393

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2664149

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