Cyclic pyrrole-imidazole polyamides targeted to the androgen response element.
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Structural Basis for Cyclic Py-Im Polyamide Allosteric Inhibition of Nuclear Receptor BindingComprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.Binding studies of a large antiviral polyamide to a natural HPV sequence.Investigation and improvement of DNA cleavage models of polyamide + Cu(II) nuclease + OOH- ligands bound to DNAMinireview: Not picking pockets: nuclear receptor alternate-site modulators (NRAMs)Replication stress by Py-Im polyamides induces a non-canonical ATR-dependent checkpoint response.Noncanonical mechanisms to regulate nuclear receptor signaling.Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing.Synthesis of cyclic Py-Im polyamide libraries.Expanding the repertoire of natural product-inspired ring pairs for molecular recognition of DNA.Solution formulation development and efficacy of MJC13 in a preclinical model of castration-resistant prostate cancerComplexity in the binding of minor groove agents: netropsin has two thermodynamically different DNA binding modes at a single site.Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns.Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide.Microwave assisted synthesis of Py-Im polyamides.Characterization and solubilization of pyrrole-imidazole polyamide aggregatesAndrogen receptor: structure, role in prostate cancer and drug discovery.Single-dose pharmacokinetic and toxicity analysis of pyrrole-imidazole polyamides in mice.Arrangement of Proteinogenic α-Amino Acids on a Cyclic Peptide Comprising Alternate Biphenyl-Cored ζ-Amino Acids.Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide.Animal toxicity of hairpin pyrrole-imidazole polyamides varies with the turn unit.Oligomerization route to Py-Im polyamide macrocycles.Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines.Androgen receptor antagonists: a patent review (2008-2011).Beyond the ligand-binding pocket: targeting alternate sites in nuclear receptors.Androgen receptor modulators: a marriage of chemistry and biology.Sequence-specific DNA recognition by cyclic pyrrole-imidazole cysteine-derived polyamide dimers.The application of fluorescence-conjugated pyrrole/imidazole polyamides in the characterization of protein-DNA complex formation.Comparative Analysis of DNA-Binding Selectivity of Hairpin and Cyclic Pyrrole-Imidazole Polyamides Based on Next-Generation Sequencing.Interactions of two large antiviral polyamides with the long control region of HPV16.Binding of hairpin pyrrole and imidazole polyamides to DNA: relationship between torsion angle and association rate constants.Catch and Release DNA Decoys: Capture and Photochemical Dissociation of NF-κB Transcription Factors.Pyrrole-imidazole polyamides distinguish between double-helical DNA and RNA.Conformational preferences of furan- and thiophene-based arylamides: a combined computational and experimental study.
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Cyclic pyrrole-imidazole polyamides targeted to the androgen response element.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Cyclic pyrrole-imidazole polyamides targeted to the androgen response element.
@en
Cyclic pyrrole-imidazole polyamides targeted to the androgen response element.
@nl
type
label
Cyclic pyrrole-imidazole polyamides targeted to the androgen response element.
@en
Cyclic pyrrole-imidazole polyamides targeted to the androgen response element.
@nl
prefLabel
Cyclic pyrrole-imidazole polyamides targeted to the androgen response element.
@en
Cyclic pyrrole-imidazole polyamides targeted to the androgen response element.
@nl
P2093
P2860
P356
P1476
Cyclic pyrrole-imidazole polyamides targeted to the androgen response element.
@en
P2093
Daniel A Harki
David M Chenoweth
John W Phillips
P2860
P304
P356
10.1021/JA901309Z
P407
P577
2009-05-01T00:00:00Z