Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia.
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High-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesotheliomaGenetic landscape and deregulated pathways in B-cell lymphoid malignancies.Identification of SETD2-NF1 fusion gene in a pediatric spindle cell tumor with the chromosomal translocation t(3;17)(p21;q12).SETD2 and histone H3 lysine 36 methylation deficiency in advanced systemic mastocytosis.Clinical Implications of Novel Genomic Discoveries in Chronic Lymphocytic Leukemia.Genomic profiling of Acute lymphoblastic leukemia in ataxia telangiectasia patients reveals tight link between ATM mutations and chromothripsis.SETting the Stage for Cancer Development: SETD2 and the Consequences of Lost Methylation.Chronic lymphocytic leukaemia genomics and the precision medicine era.EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia.Next-generation sequencing in chronic lymphocytic leukemia: recent findings and new horizons.SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia.Setd2 regulates quiescence and differentiation of adult hematopoietic stem cells by restricting RNA polymerase II elongation.Setd2 deficiency impairs hematopoietic stem cell self-renewal and causes malignant transformation.MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.
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Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 10 June 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Genomic disruption of the hist ...... chronic lymphocytic leukaemia.
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Genomic disruption of the hist ...... chronic lymphocytic leukaemia.
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Genomic disruption of the hist ...... chronic lymphocytic leukaemia.
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Genomic disruption of the hist ...... chronic lymphocytic leukaemia.
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Genomic disruption of the hist ...... chronic lymphocytic leukaemia.
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Genomic disruption of the hist ...... chronic lymphocytic leukaemia.
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Genomic disruption of the hist ...... chronic lymphocytic leukaemia
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A J Steele
A Roghanian
D G Oscier
F McNicholl
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10.1038/LEU.2016.134
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2016-05-20T00:00:00Z