Thin filament length regulation in striated muscle sarcomeres: pointed-end dynamics go beyond a nebulin ruler.
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Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenanceTropomodulin capping of actin filaments in striated muscle development and physiologyA polarised population of dynamic microtubules mediates homeostatic length control in animal cellsLarge isoforms of UNC-89 (obscurin) are required for muscle cell architecture and optimal calcium release in Caenorhabditis elegansDifferent localizations and cellular behaviors of leiomodin and tropomodulin in mature cardiomyocyte sarcomeresThe vertebrate muscle Z-disc: sarcomere anchor for structure and signallingExpression and subcellular localization of mammalian formin Fhod3 in the embryonic and adult heartMammalian formin fhod3 regulates actin assembly and sarcomere organization in striated musclesTropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiologyHow Cells Measure Length on Subcellular ScalesA nebulin ruler does not dictate thin filament lengthsMammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesis.The nebulin SH3 domain is dispensable for normal skeletal muscle structure but is required for effective active load bearing in mouse.Nebulin binding impedes mutant desmin filament assembly.Pointed-end capping by tropomodulin modulates actomyosin crossbridge formation in skeletal muscle fibers.Nebulette is a powerful cytolinker organizing desmin and actin in mouse heartsAberrant developmental titin splicing and dysregulated sarcomere length in Thymosin β4 knockout mice.Reduced myofibrillar connectivity and increased Z-disk width in nebulin-deficient skeletal muscle.Nebulin regulates actin filament lengths by a stabilization mechanism.New insights into the structural roles of nebulin in skeletal muscle.Phosphorylation of tropomodulin1 contributes to the regulation of actin filament architecture in cardiac muscle.Prolonged space flight-induced alterations in the structure and function of human skeletal muscle fibres.Regulation of structure and function of sarcomeric actin filaments in striated muscle of the nematode Caenorhabditis elegans.Dynamic regulation of sarcomeric actin filaments in striated muscleMammalian tropomodulins nucleate actin polymerization via their actin monomer binding and filament pointed end-capping activities.Cofilin-2 controls actin filament length in muscle sarcomeres.Identification of residues within tropomodulin-1 responsible for its localization at the pointed ends of the actin filaments in cardiac myocytes.Nebulin, a major player in muscle health and diseaseMuscle giants: molecular scaffolds in sarcomerogenesis.Cytoplasmic gamma-actin and tropomodulin isoforms link to the sarcoplasmic reticulum in skeletal muscle fibers.DAAM is required for thin filament formation and Sarcomerogenesis during muscle development in DrosophilaAn ongoing role for structural sarcomeric components in maintaining Drosophila melanogaster muscle function and structure.The sarcomeric protein nebulin: another multifunctional giant in charge of muscle strength optimizationThin-filament length correlates with fiber type in human skeletal muscle.Congenital myopathy-causing tropomyosin mutations induce thin filament dysfunction via distinct physiological mechanisms.Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle.Role of Active Contraction and Tropomodulins in Regulating Actin Filament Length and Sarcomere Structure in Developing Zebrafish Skeletal Muscle.NMII forms a contractile transcellular sarcomeric network to regulate apical cell junctions and tissue geometryDeleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy.Thin filament length dysregulation contributes to muscle weakness in nemaline myopathy patients with nebulin deficiency.
P2860
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P2860
Thin filament length regulation in striated muscle sarcomeres: pointed-end dynamics go beyond a nebulin ruler.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 26 August 2008
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vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Thin filament length regulatio ...... ics go beyond a nebulin ruler.
@en
Thin filament length regulatio ...... ics go beyond a nebulin ruler.
@nl
type
label
Thin filament length regulatio ...... ics go beyond a nebulin ruler.
@en
Thin filament length regulatio ...... ics go beyond a nebulin ruler.
@nl
prefLabel
Thin filament length regulatio ...... ics go beyond a nebulin ruler.
@en
Thin filament length regulatio ...... ics go beyond a nebulin ruler.
@nl
P2860
P1476
Thin filament length regulatio ...... ics go beyond a nebulin ruler.
@en
P2093
Ryan S Littlefield
P2860
P304
P356
10.1016/J.SEMCDB.2008.08.009
P50
P577
2008-08-26T00:00:00Z