Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire.
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The relationship between predicted peptide-MHC class II affinity and T-cell activation in a HLA-DRbeta1*0401 transgenic mouse modelStructure of a TCR with high affinity for self-antigen reveals basis for escape from negative selectionStructure-based design of altered MHC class II-restricted peptide ligands with heterogeneous immunogenicityT cell epitope mapping of JC polyoma virus-encoded proteome reveals reduced T cell responses in HLA-DRB1*04:01+ donorsProtein deimmunization via structure-based design enables efficient epitope deletion at high mutational loadsA molecular view of multiple sclerosis and experimental autoimmune encephalitis: what can we learn from the epitope data?Lack of restriction of T cell receptor beta variable gene usage in cerebrospinal fluid lymphocytes in acute optic neuritis.T-cell based immunotherapy in experimental autoimmune encephalomyelitis and multiple sclerosis.For many but not for all: how the conformational flexibility of the peptide/MHCII complex shapes epitope selectionFunctional HLA-DM on the surface of B cells and immature dendritic cells.Cell-surface MHC density profiling reveals instability of autoimmunity-associated HLA.HLA-DM constrains epitope selection in the human CD4 T cell response to vaccinia virus by favoring the presentation of peptides with longer HLA-DM-mediated half-livesUnique clinical and pathological features in HLA-DRB1*0401-restricted MBP 111-129-specific humanized TCR transgenic mice.Thymic versus induced regulatory T cells - who regulates the regulators?Molecular tracking of antigen-specific T cell clones in neurological immune-mediated disordersAntigen specificity of clonally expanded and receptor edited cerebrospinal fluid B cells from patients with relapsing remitting MSMyelin-reactive type B T cells and T cells specific for low-affinity MHC-binding myelin peptides escape tolerance in HLA-DR transgenic miceNaturally presented peptides on major histocompatibility complex I and II molecules eluted from central nervous system of multiple sclerosis patients.T-cell trafficking in the central nervous system.Structural basis for self-recognition by autoimmune T-cell receptors.HLA-DM Focuses on Conformational Flexibility Around P1 Pocket to Catalyze Peptide Exchange.Associations of human leukocyte antigens with autoimmune diseases: challenges in identifying the mechanism.Cathepsin S and an asparagine-specific endoprotease dominate the proteolytic processing of human myelin basic protein in vitro.Expression of cathepsins S and D signals a distinctive biochemical trait in CD34+ hematopoietic stem cells of relapsing-remitting multiple sclerosis patients.Experimental autoimmune uveitis induced by immunization with retinal pigment epithelium-specific 65-kDa protein peptides.CD8 T cell autoreactivity to preproinsulin epitopes with very low human leucocyte antigen class I binding affinity.The major histocompatibility complex and antibody-mediated limbic encephalitis.
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P2860
Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 1997
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Immunodominance of a low-affin ...... ed T cell receptor repertoire.
@en
Immunodominance of a low-affin ...... g myelin basic protein epitope
@nl
type
label
Immunodominance of a low-affin ...... ed T cell receptor repertoire.
@en
Immunodominance of a low-affin ...... g myelin basic protein epitope
@nl
prefLabel
Immunodominance of a low-affin ...... ed T cell receptor repertoire.
@en
Immunodominance of a low-affin ...... g myelin basic protein epitope
@nl
P2093
P2860
P356
P1476
Immunodominance of a low-affin ...... ed T cell receptor repertoire.
@en
P2093
H F McFarland
L R Tranquill
M Vergelli
W E Biddison
P2860
P304
P356
10.1172/JCI119539
P407
P577
1997-07-01T00:00:00Z