about
Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) responseHIV-1 Nef impairs MHC class II antigen presentation and surface expressionEndocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef proteinSelection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infectionMechanisms of HIV protein degradation into epitopes: implications for vaccine designThe major genetic determinants of HIV-1 control affect HLA class I peptide presentation.Altered response hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques.HIV-1 p24(gag) derived conserved element DNA vaccine increases the breadth of immune response in mice.A simple methodology to assess endolysosomal protease activity involved in antigen processing in human primary cells.Variable HIV peptide stability in human cytosol is critical to epitope presentation and immune escape.Variable processing and cross-presentation of HIV by dendritic cells and macrophages shapes CTL immunodominance and immune escape.The endoplasmic reticulum membrane is permeable to small molecules.Expansion of HIV-specific CD4+ and CD8+ T cells by dendritic cells transfected with mRNA encoding cytoplasm- or lysosome-targeted NefA Conserved HIV-1-Derived Peptide Presented by HLA-E Renders Infected T-cells Highly Susceptible to Attack by NKG2A/CD94-Bearing Natural Killer Cells.Immunodominance of HIV-1-specific CD8(+) T-cell responses in acute HIV-1 infection: at the crossroads of viral and host genetics.Portable flanking sequences modulate CTL epitope processing.Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women.Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replicationImmune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA.Differential HIV epitope processing in monocytes and CD4 T cells affects cytotoxic T lymphocyte recognitionAnalysis of Major Histocompatibility Complex-Bound HIV Peptides Identified from Various Cell Types Reveals Common Nested Peptides and Novel T Cell Responses.IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells.A real-time killing assay to follow viral epitope presentation to CD8 T cellsSusceptibility to CD8 T-cell-mediated killing influences the reservoir of latently HIV-1-infected CD4 T cellsSequence-specific alterations of epitope production by HIV protease inhibitors.Different antigen-processing activities in dendritic cells, macrophages, and monocytes lead to uneven production of HIV epitopes and affect CTL recognition.Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation.HIV Protease Inhibitor-Induced Cathepsin Modulation Alters Antigen Processing and Cross-PresentationMHC-I-restricted presentation of HIV-1 virion antigens without viral replication.Analysis of Nef-induced MHC-I endocytosis.Aminopeptidase substrate preference affects HIV epitope presentation and predicts immune escape patterns in HIV-infected individuals.HIV-1 gag cytotoxic T lymphocyte epitopes vary in presentation kinetics relative to HLA class I downregulation.In vitro evaluation of digestive and endolysosomal enzymes to cleave CML-modified Ara h 1 peptides.Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction.Human immunodeficiency virus type I Nef independently affects virion incorporation of major histocompatibility complex class I molecules and virus infectivity.SO4-05 OA. The intracellular production of HIV antigenic peptides is guided by predictable motifs and can be altered: implications for immunogen design.Alteration of HIV epitope processing and presentation by HIV protease inhibitors.Effect of HIV infection on the expression and the activity of the proteasome in primary CD4 T cells.Variable processing and presentation of HIV epitopes in dendritic cells and macrophages to CD8 T cells.
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description
hulumtuese
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researcher
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wetenschapper
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հետազոտող
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name
Sylvie Le Gall
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Sylvie Le Gall
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Sylvie Le Gall
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Sylvie Le Gall
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Sylvie Le Gall
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type
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Sylvie Le Gall
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Sylvie Le Gall
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Sylvie Le Gall
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Sylvie Le Gall
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Sylvie Le Gall
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Sylvie Le Gall
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Sylvie Le Gall
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Sylvie Le Gall
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Sylvie Le Gall
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Sylvie Le Gall
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P21
P31
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0000-0003-0385-926X