Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation.
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Interaction of Hic-5, A senescence-related protein, with focal adhesion kinaseRole of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migrationIntegrin alphavbeta3, requirement for VEGFR2-mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGFCAS/Crk coupling serves as a "molecular switch" for induction of cell migration.Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migrationTyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substratesRegulation of focal adhesion kinase by a novel protein inhibitor FIP200Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassemblyConcerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motilityPaxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling.Suppression of Pyk2 kinase and cellular activities by FIP200Recruitment of focal adhesion kinase and paxillin to beta1 integrin promotes cancer cell migration via mitogen activated protein kinase activationActivation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation.Glioblastoma Stem Cells Microenvironment: The Paracrine Roles of the Niche in Drug and RadioresistanceTRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and ContractilityFocal adhesion kinase regulation of N-WASP subcellular localization and functionAssociation of focal adhesion kinase with Grb7 and its role in cell migrationInteraction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102The integrin alpha 7 cytoplasmic domain regulates cell migration, lamellipodia formation, and p130CAS/Crk couplingIdentification of a novel interaction between integrin beta1 and 14-3-3betaThe PTPase YopH inhibits uptake of Yersinia, tyrosine phosphorylation of p130Cas and FAK, and the associated accumulation of these proteins in peripheral focal adhesionsActivation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cellsA role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesionsDirect association of protein-tyrosine phosphatase PTP-PEST with paxillinIntegrin-dependent signal transduction regulating cyclin D1 expression and G1 phase cell cycle progressionRegulation of fibroblast motility by the protein tyrosine phosphatase PTP-PESTRegulation of cell adhesion by protein-tyrosine phosphatases. I. Cell-matrix adhesionThe role of conserved amino acid motifs within the integrin beta3 cytoplasmic domain in triggering focal adhesion kinase phosphorylationThe protrusive phase and full development of integrin-dependent adhesions in colon epithelial cells require FAK- and ERK-mediated actin spike formation: deregulation in cancer cellsSrc mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cellsPyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration.FAK+ and PYK2/CAKbeta, two related tyrosine kinases highly expressed in the central nervous system: similarities and differences in the expression patternFocal adhesion kinase protein levels in gut epithelial motilityDecreased cell adhesion promotes angiogenesis in a Pyk2-dependent mannerConditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesisRho GTPases control polarity, protrusion, and adhesion during cell movementThe SH3 domain directs acto-myosin-dependent targeting of v-Src to focal adhesions via phosphatidylinositol 3-kinase.Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase.Phosphorylation of tyrosine residues 31 and 118 on paxillin regulates cell migration through an association with CRK in NBT-II cells.Regulation of focal adhesion targeting and inhibitory functions of the FAK related protein FRNK using a novel estrogen receptor "switch".
P2860
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P2860
Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Inhibition of focal adhesion k ...... ll motility and proliferation.
@en
Inhibition of focal adhesion kinase
@nl
type
label
Inhibition of focal adhesion k ...... ll motility and proliferation.
@en
Inhibition of focal adhesion kinase
@nl
prefLabel
Inhibition of focal adhesion k ...... ll motility and proliferation.
@en
Inhibition of focal adhesion kinase
@nl
P2860
P356
P1476
Inhibition of focal adhesion k ...... ll motility and proliferation.
@en
P2093
A P Gilmore
P2860
P304
P356
10.1091/MBC.7.8.1209
P577
1996-08-01T00:00:00Z