Organic cation transporters are determinants of oxaliplatin cytotoxicity. - sprookjes - yvandenbroek - TriplyDB

Organic cation transporters are determinants of oxaliplatin cytotoxicity.

Organic cation transporters are determinants of oxaliplatin cytotoxicity.

http://www.wikidata.org/entity/Q37416089

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Histamine type 2 receptor antagonists as adjuvant treatment for resected colorectal cancer Pharmacologic resistance in colorectal cancer: a review FOLFOX/FOLFIRI pharmacogenetics: the call for a personalized approach in colorectal cancer therapy Role of the plasma membrane transporter of organic cations OCT1 and its genetic variants in modern liver pharmacology Role of solute carriers in response to anticancer drugs cis -Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs Multidrug Resistance-Associated Protein 2 (MRP2) Mediated Transport of Oxaliplatin-Derived Platinum in Membrane Vesicles Esters of Bendamustine Are by Far More Potent Cytotoxic Agents than the Parent Compound against Human Sarcoma and Carcinoma Cells A novel approach using C. elegans DNA damage-induced apoptosis to characterize the dynamics of uptake transporters for therapeutic drug discoveries Membrane transporters as mediators of Cisplatin effects and side effects.Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions.Role of the copper transporter, CTR1, in platinum-induced ototoxicity.Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver.Differential transport of platinum compounds by the human organic cation transporter hOCT2 (hSLC22A2).Xenobiotic, bile acid, and cholesterol transporters: function and regulation.New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling Comparison of human solute carriers Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2 Cisplatin-induced renal injury is independently mediated by OCT2 and p53.Pharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 years Uptake of pramipexole by human organic cation transporters.Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function.High expression of organic anion transporter 2 and organic cation transporter 2 is an independent predictor of good outcomes in patients with metastatic colorectal cancer treated with FOLFOX-based chemotherapy.Downregulation of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) in human hepatocellular carcinoma and their prognostic significance.Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics.Nanocarriers for delivery of platinum anticancer drugs.Understanding and improving platinum anticancer drugs--phenanthriplatin Evaluation of the transporter-mediated herb-drug interaction potential of DA-9801, a standardized dioscorea extract for diabetic neuropathy, in human in vitro and rat in vivo.Role of organic cation transporter 1, OCT1 in the pharmacokinetics and toxicity of cis-diammine(pyridine)chloroplatinum(II) and oxaliplatin in mice.Interactions of tyrosine kinase inhibitors with organic cation transporters and multidrug and toxic compound extrusion proteins Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide.Third row transition metals for the treatment of cancer Spectrum of cellular responses to pyriplatin, a monofunctional cationic antineoplastic platinum(II) compound, in human cancer cells Functional characterization of liver enhancers that regulate drug-associated transporters.Platinum anticancer agents and antidepressants: desipramine enhances platinum-based cytotoxicity in human colon cancer cells Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue.Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action Assessment of the Relation between the Expression of Oxaliplatin Transporters in Colorectal Cancer and Response to FOLFOX-4 Adjuvant Chemotherapy: A Case Control Study

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Organic cation transporters are determinants of oxaliplatin cytotoxicity.

http://www.wikidata.org/entity/Q37416089

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on September 2006

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

Organic cation transporters are determinants of oxaliplatin cytotoxicity.

@en

Organic cation transporters are determinants of oxaliplatin cytotoxicity.

@nl

type

label

Organic cation transporters are determinants of oxaliplatin cytotoxicity.

@en

Organic cation transporters are determinants of oxaliplatin cytotoxicity.

@nl

prefLabel

Organic cation transporters are determinants of oxaliplatin cytotoxicity.

@en

Organic cation transporters are determinants of oxaliplatin cytotoxicity.

@nl

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0008-5472.CAN-06-0769

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Cancer Research

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Organic cation transporters are determinants of oxaliplatin cytotoxicity

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Anna Lapuk

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James E Shima

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Joe W Gray

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Kathleen M Giacomini

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Leah L Lagpacan

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Shuzhong Zhang

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Stephen J Lippard

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Takafumi Komori

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Xin Chen

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Yan Shu

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P2860

Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27

Cloning and functional expression of a human liver organic cation transporter

Cloning and characterization of two human polyspecific organic cation transporters

Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3

Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1

2.4 A crystal structure of an oxaliplatin 1,2-d(GpG) intrastrand cross-link in a DNA dodecamer duplex

Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin

Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function

Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance

Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter

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8847-8857

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scholarly article

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10.1158/0008-5472.CAN-06-0769

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17

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Katherine Lovejoy

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2006-09-01T00:00:00Z

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16951202

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