A high Notch pathway activation predicts response to γ secretase inhibitors in proneural subtype of glioma tumor-initiating cells. - sprookjes - yvandenbroek - TriplyDB

A high Notch pathway activation predicts response to γ secretase inhibitors in proneural subtype of glioma tumor-initiating cells.

A high Notch pathway activation predicts response to γ secretase inhibitors in proneural subtype of glioma tumor-initiating cells.

http://www.wikidata.org/entity/Q37626395

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Radioresistance of Brain Tumors Targeting Notch to overcome radiation resistance Cancer stem cell targeted therapy: progress amid controversies.Mammary gland stem cells and their application in breast cancer Micro-masters of glioblastoma biology and therapy: increasingly recognized roles for microRNAs.The interference of Notch1 target Hes1 affects cell growth, differentiation and invasiveness of glioblastoma stem cells through modulation of multiple oncogenic targets Actin cytoskeleton regulator Arp2/3 complex is required for DLL1 activating Notch1 signaling to maintain the stem cell phenotype of glioma initiating cells.Promoting oligodendroglial-oriented differentiation of glioma stem cell: a repurposing of quetiapine for the treatment of malignant glioma Casein Kinase 2: a novel player in glioblastoma therapy and cancer stem cells.Glial progenitors as targets for transformation in glioma.Prevention against diffuse spinal cord astrocytoma: can the Notch pathway be a novel treatment target?Increased Notch Signaling Enhances Radioresistance of Malignant Stromal Cells Induced by Glioma Stem/ Progenitor Cells Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update LncRNA NALT interaction with NOTCH1 promoted cell proliferation in pediatric T cell acute lymphoblastic leukemia.Enhanced expression of Vastatin inhibits angiogenesis and prolongs survival in murine orthotopic glioblastoma model.Suppression of RAF/MEK or PI3K synergizes cytotoxicity of receptor tyrosine kinase inhibitors in glioma tumor-initiating cells.Alterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells.The Cancer Genome Atlas Analysis Predicts MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma.The Notch pathway promotes the cancer stem cell characteristics of CD90+ cells in hepatocellular carcinoma Bruceantin inhibits multiple myeloma cancer stem cell proliferation.EFEMP1 induces γ-secretase/Notch-mediated temozolomide resistance in glioblastoma.Notching on Cancer's Door: Notch Signaling in Brain Tumors.The Potential Roles of Long Noncoding RNAs (lncRNA) in Glioblastoma Development.Notch3 signaling-mediated melanoma-endothelial crosstalk regulates melanoma stem-like cell homeostasis and niche morphogenesis.MSK1-Mediated β-Catenin Phosphorylation Confers Resistance to PI3K/mTOR Inhibitors in Glioblastoma.Inhibition of autophagy induced by quercetin at a late stage enhances cytotoxic effects on glioma cells.Effect of Notch expression in glioma stem cells on therapeutic response to chemo-radiotherapy in recurrent glioblastoma.Notch1 stimulation induces a vascularization switch with pericyte-like cell differentiation of glioblastoma stem cells.Molecular and Clinical Effects of Notch Inhibition in Glioma Patients: A Phase 0/I Trial.Targeting Notch Signaling and Autophagy Increases Cytotoxicity in Glioblastoma Neurospheres.Epigenetic regulation of NOTCH1 and NOTCH3 by KMT2A inhibits glioma proliferation.Patient-derived glioblastoma stem cells respond differentially to targeted therapies.γ-Secretase inhibitor-resistant glioblastoma stem cells require RBPJ to propagate Fibroblast growth factor 13 regulates glioma cell invasion and is important for bevacizumab-induced glioma invasion.IndividualizedPath: identifying genetic alterations contributing to the dysfunctional pathways in glioblastoma individuals.Autophagy suppression potentiates the anti-glioblastoma effect of asparaginase in vitro and in vivo.Notch1 ablation radiosensitizes glioblastoma cells.Activation of WEE1 confers resistance to PI3K inhibition in glioblastoma.Inhibition of Farnesyltransferase Potentiates NOTCH-Targeted Therapy against Glioblastoma Stem Cells.[(3) H]-L685,458 binding sites are abundant in multiple peripheral organs in rats: implications for safety assessment of putative γ-secretase targeting drugs.

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A high Notch pathway activation predicts response to γ secretase inhibitors in proneural subtype of glioma tumor-initiating cells.

http://www.wikidata.org/entity/Q37626395

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

@pt

bilimsel makale

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scientific article published on January 2014

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

A high Notch pathway activatio ...... glioma tumor-initiating cells.

@en

A high Notch pathway activatio ...... glioma tumor-initiating cells.

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type

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A high Notch pathway activatio ...... glioma tumor-initiating cells.

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A high Notch pathway activatio ...... glioma tumor-initiating cells.

@nl

prefLabel

A high Notch pathway activatio ...... glioma tumor-initiating cells.

@en

A high Notch pathway activatio ...... glioma tumor-initiating cells.

@nl

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A high Notch pathway activatio ...... glioma tumor-initiating cells.

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Diane D Liu

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Dimpy Koul

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Erik P Sulman

http://www.w3.org/2001/XMLSchema#string

Frederick F Lang

http://www.w3.org/2001/XMLSchema#string

Howard Colman

http://www.w3.org/2001/XMLSchema#string

Jun Fu

http://www.w3.org/2001/XMLSchema#string

Jun Yao

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Norihiko Saito

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Roel G Verhaak

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Shuzhen Wang

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P2860

Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

Calibration and assessment of channel-specific biases in microarray data with extended dynamical range

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

Identification of human brain tumour initiating cells

The Notch-Hes pathway in mammalian neural development

KEGG for integration and interpretation of large-scale molecular data sets

The canonical Notch signaling pathway: unfolding the activation mechanism.

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301-312

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scholarly article

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10.1002/STEM.1528

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1

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32

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2014-01-01T00:00:00Z

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256613025

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24038660

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3947402

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