Ribozyme-mediated cleavage of c-fos mRNA reduces gene expression of DNA synthesis enzymes and metallothionein.
about
Targeted disruption of the c-fos gene demonstrates c-fos-dependent and -independent pathways for gene expression stimulated by growth factors or oncogenesNeuronal NOS inhibitor that reduces oxidative DNA lesions and neuronal sensitivity increases the expression of intact c-fos transcripts after brain injuryIdentification of gene function and functional pathways by systemic plasmid-based ribozyme targeting in adult miceCurrent status of ribozymes as gene therapy agents for cancer.Tissue-specific expression of an anti-ras ribozyme inhibits proliferation of human malignant melanoma cells.Design and specificity of hammerhead ribozymes against calretinin mRNA.Status of ribozyme and antisense-based developmental approaches for anti-HIV-1 therapy.Molecular mechanisms of resistance and toxicity associated with platinating agents.Localization of Fos and Jun proteins in rat aortic smooth muscle cells after vascular injury.Ribozyme-mediated reversal of the multidrug-resistant phenotype.Multitarget-ribozyme directed to cleave at up to nine highly conserved HIV-1 env RNA regions inhibits HIV-1 replication--potential effectiveness against most presently sequenced HIV-1 isolates.Reversion of multidrug resistance in the P-glycoprotein-positive human pancreatic cell line (EPP85-181RDB) by introduction of a hammerhead ribozyme.Use of ribozymes and antisense oligodeoxynucleotides to investigate mechanisms of drug resistanceRibozyme-mediated inactivation of mutant K-ras oncogene in a colon cancer cell line.Down-regulation of Fas-L in glioma cells by ribozyme reduces cell apoptosis, tumour-infiltrating cells, and liver damage but accelerates tumour formation in nude mice.Ribozyme-mediated high resistance against potato spindle tuber viroid in transgenic potatoes.Oxidative damage to the c-fos gene and reduction of its transcription after focal cerebral ischemia.Suppression of ischemia-induced fos expression and AP-1 activity by an antisense oligodeoxynucleotide to c-fos mRNA.Ribozyme-mediated cleavage of the MDR-1 transcript restores chemosensitivity in previously resistant cancer cells.New and potential clinical applications of KRAS as a cancer biomarker.Replication across O6-methylguanine by human DNA polymerase beta in vitro. Insights into the futile cytotoxic repair and mutagenesis of O6-methylguanine.The efficiency of a cis-cleaving ribozyme in an mRNA coding region is influenced by the translating ribosome in vivoModification of glucose and glutamine metabolism in hybridoma cells through metabolic engineering.Can hammerhead ribozymes be efficient tools to inactivate gene function?Reduced beta 2-microglobulin mRNA levels in transgenic mice expressing a designed hammerhead ribozyme.Ribozyme mediated degradation of beta-amyloid peptide precursor mRNA in COS-7 cells.Dynamics of the metal-dependent transcription factor complex in vivo at the mouse metallothionein-I promoter.Specific inhibition of DNA polymerase beta by its 14 kDa domain: role of single- and double-stranded DNA binding and 5'-phosphate recognition.In vivo decay kinetic parameters of hammerhead ribozymes.c-Fos activated phospholipid synthesis is required for neurite elongation in differentiating PC12 cells.Facilitation of hammerhead ribozyme catalysis by the nucleocapsid protein of HIV-1 and the heterogeneous nuclear ribonucleoprotein A1Genomic imbalances associated with acquired resistance to platinum analogues.The activation and activity control of AP-1 (fos/jun).Antisense technology for cancer therapy: does it make sense?Gene therapy for cancer: what have we done and where are we going?Mitochondrial membrane potential regulation is independent of c-fos expression.A novel SV40-based vector successfully transduces and expresses an alpha 1-antitrypsin ribozyme in a human hepatoma-derived cell line.Effect of hammerhead ribozyme against human thymidylate synthase on the cytotoxicity of thymidylate synthase inhibitors.Gene transfer in haematological malignancy.Comparison of different ribozymes for efficient and specific cleavage of BCR/ABL related mRNAs.
P2860
Q24594918-6E6842E6-9680-4982-AC3A-B080F0849664Q28344063-4E02412E-EBED-40FA-96BE-17428B209E1EQ34020968-4085AA16-802A-4981-9AB8-D944B0A2D632Q34311089-C2D8E813-5E7A-4B79-BA73-ADA1CA83C263Q34591429-08E556F2-65DD-4125-8B09-00899D251E89Q35020155-AD90517D-083D-45D1-921C-2441CB24EF2AQ35241689-9F3AFD2D-EFB8-436C-AF5E-164F044FEC20Q35758048-5DBBB855-3417-40EB-9DD1-08762BD594D5Q35832425-BF60057E-9967-457E-93D9-45926BEB5787Q35897342-81D3C736-1C75-47FE-A6CD-63F03C8CC22FQ35927204-C2641496-B8B6-49F1-84A6-29BB86966FD6Q36079966-0AF09ABF-082F-4E85-BBA6-7D5094BC5AC5Q36254793-8B8A4644-DDAE-47AF-9F54-7A3BC1C31B08Q36621890-A52B895D-92D3-44E3-A6C3-C557F7BEA958Q36643564-C8E3A7DA-520D-49DD-A940-527205801CF9Q36762192-8A741A57-5852-495E-8CAE-0A07B46E6449Q37259819-58798463-535B-4A7C-981D-2B3E7048794FQ37272880-C442C4B9-83E7-4ADB-A7C8-EBB215458F87Q37636860-99A30112-8AD2-412A-8982-7761D8FF09CDQ38089885-F309794F-B4AD-4843-BF4D-3EEE9E5F2F31Q39114338-1799D05E-84FD-4BA4-91DF-C5C15307F6BBQ39721587-45B34B70-86FD-49CC-89E3-676BC44EE33EQ39918023-050BAA2C-0799-4AC8-8B44-8DBD558288C7Q40224978-9FF4E571-6A29-4CAB-BE0A-ADF7751FB5FEQ40228623-4CCDF00E-88B9-4BC7-88C3-41BF3444A307Q40229292-8F385224-D3D8-485E-A8B8-E4A030086456Q40315387-73EE5DC1-23BA-4A52-9105-7AFC14BAFDCCQ40393937-C04B31E8-D9DB-4D50-8BF0-D6CA6D57ED10Q40410270-599E36D5-3A48-4F60-8108-EDD8B62B9104Q40725776-7DFA184B-CB4C-4D96-A08D-DD32D6D3DEBEQ40792302-DFAC5DA5-A7EF-455B-8760-74CBCCA75DDCQ40807070-365E3F77-3142-4095-B868-E9D9BBA82520Q40818992-576E076E-A9C6-4793-BCF7-C62272C429F5Q40908388-C4378933-15DF-40CC-92AC-05950AA8E383Q40916302-E4892B1C-1F23-4618-9EEF-5D5C0BC17B15Q40921288-284431DA-8505-489B-A6D3-3C37CA3E4B1CQ40952202-587E150D-54F8-472A-9625-C5B6D73F3F0BQ41276215-F3423734-AA71-4BBB-BEBE-720CEBA9FC42Q41337488-62EEDB05-1AAA-4D9A-B97E-BE1A20B5F44EQ41493198-D1BE56DD-61A5-4EB3-BA43-06EBEFDFD79D
P2860
Ribozyme-mediated cleavage of c-fos mRNA reduces gene expression of DNA synthesis enzymes and metallothionein.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 1991
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Ribozyme-mediated cleavage of ...... s enzymes and metallothionein.
@en
Ribozyme-mediated cleavage of ...... s enzymes and metallothionein.
@nl
type
label
Ribozyme-mediated cleavage of ...... s enzymes and metallothionein.
@en
Ribozyme-mediated cleavage of ...... s enzymes and metallothionein.
@nl
prefLabel
Ribozyme-mediated cleavage of ...... s enzymes and metallothionein.
@en
Ribozyme-mediated cleavage of ...... s enzymes and metallothionein.
@nl
P2093
P2860
P356
P1476
Ribozyme-mediated cleavage of ...... s enzymes and metallothionein.
@en
P2093
K J Scanlon
M Kashani-Sabet
P2860
P304
10591-10595
P356
10.1073/PNAS.88.23.10591
P407
P577
1991-12-01T00:00:00Z