The LAT story: a tale of cooperativity, coordination, and choreography. - sprookjes - yvandenbroek - TriplyDB

The LAT story: a tale of cooperativity, coordination, and choreography.

The LAT story: a tale of cooperativity, coordination, and choreography.

http://www.wikidata.org/entity/Q37770817

about

Classification of intrinsically disordered regions and proteins ELM--the database of eukaryotic linear motifs Signaling in T cells - is anything the m(a)TOR with the picture(s)?Motif co-regulation and co-operativity are common mechanisms in transcriptional, post-transcriptional and post-translational regulation Super-resolution characterization of TCR-dependent signaling clusters Normal Development and Function of T Cells in Proline Rich 7 (Prr7) Deficient Mice Hierarchical nanostructure and synergy of multimolecular signalling complexes.Experimental detection of short regulatory motifs in eukaryotic proteins: tips for good practice as well as for bad Capturing cooperative interactions with the PSI-MI format Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-γ1 Activation and Cytokine Production.A peptide-functionalized polymer as a minimal scaffold protein to enhance cluster formation in early T cell signal transduction.The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms.GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.LAT-independent Erk activation via Bam32-PLC-γ1-Pak1 complexes: GTPase-independent Pak1 activation.Cutting edge: cell surface linker for activation of T cells is recruited to microclusters and is active in signaling Molecular mechanisms underlying the evolution of the slp76 signalosome.HIV-1 Nef: a multifaceted modulator of T cell receptor signaling.RasGRP1, but not RasGRP3, is required for efficient thymic β-selection and ERK activation downstream of CXCR4 Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation.The human CD8β M-4 isoform dominant in effector memory T cells has distinct cytoplasmic motifs that confer unique properties.The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo.Oligomerization and nanocluster organization render specificity.GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cells Immune synapse: conductor of orchestrated organelle movement.Regulation of T cell development by c-Cbl: essential role of Lck.Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor.Immunoreceptor signaling miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways Transmembrane adaptor proteins in the high-affinity IgE receptor signaling Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration.Probing protein heterogeneity in the plasma membrane using PALM and pair correlation analysis.Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha The linker for activation of T cells (LAT) signaling hub: from signaling complexes to microclusters The human cytomegalovirus glycoprotein pUL11 acts via CD45 to induce T cell IL-10 secretion.Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain.A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.Signaling for synergistic activation of natural killer cells.TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.

P2860

Q22061736-41433582-82B3-4D71-B392-8ACBA3599AA6 Q24621147-24296EE4-6F46-4F8E-8C15-9E87B026AA2C Q26767443-ED178189-96C7-4DC6-8495-75EBF37F7D94 Q26775592-31B5DA6B-31BA-45D0-9B86-05ACDF248428 Q27015450-BB07E99C-5D19-4E69-A75B-FD48279DBF5B Q27322365-4BABF973-E080-47F3-90BD-BD33EF160DD5 Q27336137-6B468E5D-731C-4399-90B0-2262E7EEC02F Q28083241-D8019E1B-CF4F-4999-9DAC-D72C422214CC Q28679243-0090CF6A-A044-4F71-9F75-4C3B71B1D475 Q28771480-C5021027-4789-4FAC-8B56-A812F99E2FDC Q30009190-8D64EEC6-8527-46BA-AA4C-2D2EFE053072 Q30009227-92758C85-94D4-46F1-A525-7FDC84AA74CD Q30009507-DC0A51F7-28BE-41A3-9123-CE674B3B9FDD Q30009907-CAA87EFF-5BA7-413D-B800-EB90D62C954E Q30010009-D5CBFA24-8DC5-4363-A21E-3677DEF7F742 Q30586313-3B2EC928-E2B7-4550-841C-1F0906120051 Q33685537-18AF4A91-78CE-4745-90E0-0D98BAF09889 Q34316824-FF600C04-5F4C-4651-9BEA-4B51DA2E4316 Q34544903-37BFB550-730A-473D-BC0F-BA1DA7CC26BE Q34583014-CDFD66CF-33F8-4943-BE48-C414AF6E21BF Q34637799-FE5B692C-0E48-44C3-95EE-54E1771A4A5C Q34655627-1CA6B3C7-0B79-4221-8046-1E0B9D9F8862 Q34681546-C4C7C58A-492F-47CA-AFAC-E611BABC423A Q35118388-A54CEFA8-02C5-4C5C-BF5B-599A2DDF7FCE Q35141243-86735185-F815-4639-B4F3-3F132676703B Q35524069-3801DE0A-664D-4564-8C6C-A49B8078747C Q35577665-FAB9D26C-E75B-434D-9AC5-3448D72E24EB Q35578452-5E5FE711-BD33-4D4B-8D06-F3AB1C015F3F Q35676981-06F81394-D97C-413E-B895-F64A02873C9D Q35927627-D65C0F90-F233-4388-802C-12CBCAE62312 Q35952285-8B9A2691-8BF3-40AB-94F4-DB211A483482 Q36103862-B063D902-A6DF-4EC9-BF8C-DD2156894F4A Q36151999-42050C21-6166-453F-AAD3-6C0EDAC259C6 Q36283658-890CCDEA-0227-4B8B-98E3-79283F433355 Q36409239-30008ABF-FBF6-45D1-8A2D-346E6248455D Q36478261-997F6740-F4B1-4A62-B387-A3B9F79850FF Q36487572-EF76DBB3-D93E-4307-BC47-6FCA30892106 Q36592767-F3D204B3-C8F5-4E1A-827F-294C7EC100EB Q36754365-9F11975E-F4FA-4599-9D4F-45E9EFA7BBEC Q37047281-06373653-C267-4355-9E44-E0FBE91C48CB

P2860

The LAT story: a tale of cooperativity, coordination, and choreography.

http://www.wikidata.org/entity/Q37770817

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 07 July 2010

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

The LAT story: a tale of cooperativity, coordination, and choreography.

@en

The LAT story: a tale of cooperativity, coordination, and choreography.

@nl

type

label

The LAT story: a tale of cooperativity, coordination, and choreography.

@en

The LAT story: a tale of cooperativity, coordination, and choreography.

@nl

prefLabel

The LAT story: a tale of cooperativity, coordination, and choreography.

@en

The LAT story: a tale of cooperativity, coordination, and choreography.

@nl

P1433

Q37770817-7F7E5E8C-D15A-46F9-9342-FE2BD7D6E87E

P1476

Q37770817-57F32A80-850E-4334-8371-80673BDFBBEB

P2093

Q37770817-265656A8-AD4B-4B9B-9D85-D3D439C3D489

Q37770817-9D7877EA-4E05-43D0-B4B3-F54BC6C0344D

Q37770817-AF875F79-7F9D-4326-B6D5-81D84917A198

Q37770817-D2CB5F79-4DC5-4DAF-950E-DC22AEC9457E

Q37770817-D3C22EBB-E3A2-43AA-910C-CACDC8026F25

P2860

Q37770817-0008762C-B8A4-45D6-8CE9-F0AEC4F54AC8

Q37770817-02374580-0088-47E5-976A-57759E4DAD7D

Q37770817-03B16705-02DC-4193-8E43-C2EEE3E61272

Q37770817-03DE695C-58AA-460B-B9FF-82605B5088FD

Q37770817-059903FE-8CE9-4E86-A872-26DE4F54E481

Q37770817-073C9895-D441-4A6B-878C-6D0356FEBB66

Q37770817-090DCA13-FC86-421B-9F34-BCCAB42A3275

Q37770817-0B4048DE-C6CF-48B3-B344-6B23C8962CDA

Q37770817-0C25F6D5-505B-49DA-9C72-AFE088140920

Q37770817-0DBF40E2-8865-4400-A46A-39F416766961

P304

Q37770817-CE41B694-9E78-4046-AC55-B5DBCD00DC50

P31

Q37770817-04E9B85B-7917-4014-98CB-C709C316EA00

P356

Q37770817-FD1AC1B0-096E-40CA-9A11-DC1829C53C1D

P433

Q37770817-706BAC24-0614-40A0-A539-9427718E232F

P478

Q37770817-948C1B8F-3CE8-4868-8628-1F40111AD284

P577

Q37770817-3400CEB7-99C0-4EEA-B92A-43388660D2BB

P5875

Q37770817-222FB47B-48BE-4997-B406-9D81FBD373B0

P698

Q37770817-896AA506-8908-4976-A608-CD718EDF27B2

P932

Q37770817-E093DAA3-8550-40D1-B941-9C999C246F00

P356

CSHPERSPECT.A005512

P1433

Cold Spring Harbor Perspectives in Biology

P1476

The LAT story: a tale of cooperativity, coordination, and choreography.

@en

P2093

Connie L Sommers

http://www.w3.org/2001/XMLSchema#string

Eilon Sherman

http://www.w3.org/2001/XMLSchema#string

Lakshmi Balagopalan

http://www.w3.org/2001/XMLSchema#string

Lawrence E Samelson

http://www.w3.org/2001/XMLSchema#string

Nathan P Coussens

http://www.w3.org/2001/XMLSchema#string

P2860

Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation

Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains

Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1

Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes

Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains

Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav

Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade

The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling

P304

a005512

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1101/CSHPERSPECT.A005512

http://www.w3.org/2001/XMLSchema#string

P433

8

http://www.w3.org/2001/XMLSchema#string

P478

2

http://www.w3.org/2001/XMLSchema#string

P577

2010-07-07T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

45101437

http://www.w3.org/2001/XMLSchema#string

P698

20610546

http://www.w3.org/2001/XMLSchema#string

P932

2908767

http://www.w3.org/2001/XMLSchema#string