Drug discovery approaches to target Wnt signaling in cancer stem cells. - sprookjes - yvandenbroek - TriplyDB

Drug discovery approaches to target Wnt signaling in cancer stem cells.

Drug discovery approaches to target Wnt signaling in cancer stem cells.

http://www.wikidata.org/entity/Q37840943

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Promising Druggable Target in Head and Neck Squamous Cell Carcinoma: Wnt Signaling A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers Oncostatic-Cytoprotective Effect of Melatonin and Other Bioactive Molecules: A Common Target in Mitochondrial Respiration Targeting head and neck tumoral stem cells: From biological aspects to therapeutic perspectives Autophagy in Cancer Stem Cells: A Potential Link Between Chemoresistance, Recurrence, and Metastasis Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy PI3K/Akt/mTOR signaling pathway in cancer stem cells: from basic research to clinical application Targeting the Wnt pathways for therapies Is Wilms tumor a candidate neoplasia for treatment with WNT/β-catenin pathway modulators?--A report from the renal tumors biology-driven drug development workshop Crosstalk of the Insulin-Like Growth Factor Receptor with the Wnt Signaling Pathway in Breast Cancer Current Understanding on EGFR and Wnt/β-Catenin Signaling in Glioma and Their Possible Crosstalk Targeted therapy for hepatocellular carcinoma: novel agents on the horizon GSK-3 as potential target for therapeutic intervention in cancer Advances in targeting signal transduction pathways Mantle cell lymphoma in the era of precision medicine-diagnosis, biomarkers and therapeutic agents Sustained proliferation in cancer: Mechanisms and novel therapeutic targets KIAA1199 promotes migration and invasion by Wnt/β-catenin pathway and MMPs mediated EMT progression and serves as a poor prognosis marker in gastric cancer.Cancer stem cell theory and the warburg effect, two sides of the same coin?Hedgehog signaling pathway in colorectal cancer: function, mechanism, and therapy.Transient mTOR inhibition facilitates continuous growth of liver tumors by modulating the maintenance of CD133+ cell populations.Novel clinical therapeutics targeting the epithelial to mesenchymal transition High-throughput chemical screens identify disulfiram as an inhibitor of human glioblastoma stem cells.Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer.Calcein-effluxing human colon cancer cells are enriched for self-renewal capacity and depend on β-catenin.Small molecule inhibitors in acute myeloid leukemia: from the bench to the clinic The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer.WNT7A/β-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer.The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer Differentiation of breast cancer stem cells by knockdown of CD44: promising differentiation therapy Pre-clinical efficacy of combined therapy with novel β-catenin antagonist BC2059 and histone deacetylase inhibitor against AML cells Recent progress in targeting cancer.Dietary compound isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylation.Cancer drug pan-resistance: pumps, cancer stem cells, quiescence, epithelial to mesenchymal transition, blocked cell death pathways, persisters or what?miRNA-regulated delivery of lincRNA-p21 suppresses β-catenin signaling and tumorigenicity of colorectal cancer stem cells Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells Cancer stem cell theory: therapeutic implications for nanomedicine.Phosphosulindac (OXT-328) selectively targets breast cancer stem cells in vitro and in human breast cancer xenografts Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance Novel role of STRAP in progression and metastasis of colorectal cancer through Wnt/β-catenin signaling.HMGA1 promotes metastatic processes in basal-like breast cancer regulating EMT and stemness.

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P2860

Drug discovery approaches to target Wnt signaling in cancer stem cells.

http://www.wikidata.org/entity/Q37840943

description

2010 nî lūn-bûn

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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2010年學術文章

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name

Drug discovery approaches to target Wnt signaling in cancer stem cells.

@en

Drug discovery approaches to target Wnt signaling in cancer stem cells.

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type

label

Drug discovery approaches to target Wnt signaling in cancer stem cells.

@en

Drug discovery approaches to target Wnt signaling in cancer stem cells.

@nl

prefLabel

Drug discovery approaches to target Wnt signaling in cancer stem cells.

@en

Drug discovery approaches to target Wnt signaling in cancer stem cells.

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ONCOTARGET.101016

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Drug discovery approaches to target Wnt signaling in cancer stem cells.

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Joshua C Curtin

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Matthew V Lorenzi

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Creative Commons Attribution 2.5 Unported

P2860

Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study.

Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium

A new secreted protein that binds to Wnt proteins and inhibits their activities

Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

LDL-receptor-related proteins in Wnt signal transduction

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

Methylation-associated silencing of SFRP1 with an 8p11-12 amplification inhibits canonical and non-canonical WNT pathways in breast cancers

Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation

Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action

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biomedical investigative technique

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