Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking.
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Caspase-8 as a regulator of tumor cell motilityMembrane trafficking in podocyte health and diseasePhosphoinositides: Key modulators of energy metabolismThe proline-rich tyrosine kinase Pyk2 regulates platelet integrin αIIbβ3 outside-in signaling.Sodium and potassium regulate endothelial phospholipase C-γ and Bmx.Suppression of cell migration by phospholipase C-related catalytically inactive protein-dependent modulation of PI3K signallingObligatory role for endothelial heparan sulphate proteoglycans and caveolae internalization in catestatin-dependent eNOS activationThe PI3K regulatory subunits p55α and p50α regulate cell death in vivo.Loss-of-function RNAi screens in breast cancer cells identify AURKB, PLK1, PIK3R1, MAPK12, PRKD2, and PTK6 as sensitizing targets of rapamycin activityIdentification of mutations in distinct regions of p85 alpha in urothelial cancer.PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.Thyroid hormone receptors and cancer.Effect of aging and dietary salt and potassium intake on endothelial PTEN (Phosphatase and tensin homolog on chromosome 10) function.APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain.Endocytic Trafficking at the Mature Podocyte Slit Diaphragm.Transforming growth factor-β regulates endothelial function during high salt intake in rats.β-Arrestin-kinase scaffolds: turn them on or turn them off?ErbB2-positive mammary tumors can escape PI3K-p110α loss through downregulation of the Pten tumor suppressor.Duvelisib: a phosphoinositide-3 kinase δ/γ inhibitor for chronic lymphocytic leukemia.Phosphatidylinositol 3-kinase and Rab5 GTPase inversely regulate the Smad anchor for receptor activation (SARA) protein independently of transforming growth factor-β1.Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85α and p85β.Phosphoinositide 3-kinase at the crossroad between endocytosis and signaling of cytokine receptors.Synergistic targeting of the regulatory and catalytic subunits of PI3Kδ in mature B cell malignancies.Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP3 Signaling.PI3K in cancer: its structure, activation modes and role in shaping tumor microenvironment.Folic Acid Protects Against Glutamate-Induced Excitotoxicity in Hippocampal Slices Through a Mechanism that Implicates Inhibition of GSK-3β and iNOS.New miRNA expression abnormalities in laryngeal squamous cell carcinoma.Profiling of phosphatidylinositol 3-kinase (PI3K) proteins in insulin signaling pathway.Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation.
P2860
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P2860
Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking.
description
article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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Multiple roles for the p85α is ...... ling and receptor trafficking.
@en
Multiple roles for the p85α is ...... ling and receptor trafficking.
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label
Multiple roles for the p85α is ...... ling and receptor trafficking.
@en
Multiple roles for the p85α is ...... ling and receptor trafficking.
@nl
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Multiple roles for the p85α is ...... ling and receptor trafficking.
@en
Multiple roles for the p85α is ...... ling and receptor trafficking.
@nl
P2093
P2860
P356
P1433
P1476
Multiple roles for the p85α is ...... ling and receptor trafficking.
@en
P2093
Deborah H Anderson
Jennifer N K Nyarko
Levi A Furber
Paul Mellor
P2860
P356
10.1042/BJ20111164
P407
P577
2012-01-01T00:00:00Z