The p85alpha subunit of phosphatidylinositol 3'-kinase binds to and stimulates the GTPase activity of Rab proteins
about
Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitorsTargeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria.Caspase-8 as a regulator of tumor cell motilityPhosphoinositides: Key modulators of energy metabolismMultiple phosphatidylinositol 3-kinases regulate vaccinia virus morphogenesisAmino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1.Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networksRegulation of the PI3K pathway through a p85α monomer-homodimer equilibriumThe connexin43-interacting protein, CIP85, mediates the internalization of connexin43 from the plasma membrane.Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase.Mechanism of influenza A virus NS1 protein interaction with the p85beta, but not the p85alpha, subunit of phosphatidylinositol 3-kinase (PI3K) and up-regulation of PI3K activity.GTPase activating protein function of p85 facilitates uptake and recycling of the beta1 integrinClass IA phosphatidylinositol 3-kinase p110α regulates phagosome maturation.The smaller isoforms of ankyrin 3 bind to the p85 subunit of phosphatidylinositol 3'-kinase and enhance platelet-derived growth factor receptor down-regulation.Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradationIdentification of mutations in distinct regions of p85 alpha in urothelial cancer.Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85alpha Src homology-2 domainsSignal transducer and activator of transcription 3 and the phosphatidylinositol 3-kinase regulatory subunits p55α and p50α regulate autophagy in vivo.T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling.Identification of components of the host type IA phosphoinositide 3-kinase pathway that promote internalization of Listeria monocytogenes.Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling.Ether-linked diglycerides inhibit vascular smooth muscle cell growth via decreased MAPK and PI3K/Akt signaling.Caspase 8 promotes peripheral localization and activation of Rab5.Molecular mimicry and immunomodulation by the HRES-1 endogenous retrovirus in SLE.Ligand-induced EpoR internalization is mediated by JAK2 and p85 and is impaired by mutations responsible for primary familial and congenital polycythemiaRole of p85α in neutrophil extra- and intracellular reactive oxygen species generation.Phosphoinositide 3-kinases in cell migration.The structural basis of PI3K cancer mutations: from mechanism to therapy.Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases.Endogenous retroviral pathogenesis in lupus.The regulation of class IA PI 3-kinases by inter-subunit interactions.Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking.Phosphoinositides and cytokinesis: the "PIP" of the iceberg.PI3King the right partner: unique interactions and signaling by p110β.Study of vaccinia and cowpox viruses' replication in Rac1-N17 dominant-negative cells.Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis.Coordination of the Rab5 cycle on macropinosomes.Phosphatidylinositol 3-kinase and Rab5 GTPase inversely regulate the Smad anchor for receptor activation (SARA) protein independently of transforming growth factor-β1.Rab5A is associated with axillary lymph node metastasis in breast cancer patients.Class IA PI3K p110β subunit promotes autophagy through Rab5 small GTPase in response to growth factor limitation
P2860
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P2860
The p85alpha subunit of phosphatidylinositol 3'-kinase binds to and stimulates the GTPase activity of Rab proteins
description
2004 nî lūn-bûn
@nan
2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
The p85alpha subunit of phosph ...... TPase activity of Rab proteins
@ast
The p85alpha subunit of phosph ...... TPase activity of Rab proteins
@en
The p85alpha subunit of phosph ...... TPase activity of Rab proteins
@nl
type
label
The p85alpha subunit of phosph ...... TPase activity of Rab proteins
@ast
The p85alpha subunit of phosph ...... TPase activity of Rab proteins
@en
The p85alpha subunit of phosph ...... TPase activity of Rab proteins
@nl
prefLabel
The p85alpha subunit of phosph ...... TPase activity of Rab proteins
@ast
The p85alpha subunit of phosph ...... TPase activity of Rab proteins
@en
The p85alpha subunit of phosph ...... TPase activity of Rab proteins
@nl
P2093
P2860
P3181
P356
P1476
The p85alpha subunit of phosph ...... TPase activity of Rab proteins
@en
P2093
Deborah H Anderson
M Chris Pastor
M Dean Chamberlain
Tangyne R Berry
P2860
P304
P3181
P356
10.1074/JBC.M409769200
P407
P577
2004-11-19T00:00:00Z