Prospects for new antibiotics: a molecule-centered perspective.
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Chemical structure and pharmacokinetics of novel quinolone agents represented by avarofloxacin, delafloxacin, finafloxacin, zabofloxacin and nemonoxacinCrystal Structure of Carboxyltransferase from Staphylococcus aureus Bound to the Antibacterial Agent Moiramide BThe global threat of antimicrobial resistance: science for interventionA Complete Pathway Model for Lipid A Biosynthesis in Escherichia coliEndless Resistance. Endless Antibiotics?Assembly and clustering of natural antibiotics guides target identificationThe slippery difficulty of ever containing drug resistance with current practicesAntibiotics in the clinical pipeline at the end of 2015.Crystallographic evidence of drastic conformational changes in the active site of a flavin-dependent N-hydroxylase.Nitroso Diels-Alder (NDA) reaction as an efficient tool for the functionalization of diene-containing natural productsX-ray crystal structure of teicoplanin A₂-2 bound to a catalytic peptide sequence via the carrier protein strategy.Crystal structure of 2-[(3S,4S)-4-(anthracen-9-yl)-1-(4-meth-oxy-phen-yl)-2-oxoazetidin-3-yl]-2-aza-2H-phenalene-1,3-dione unknown solvate.Drug repurposing as an alternative for the treatment of recalcitrant bacterial infections.Equisetin, reutericyclin and streptolodygin as natural product lead structures for novel antibiotic libraries.The photochemical thiol-ene reaction as a versatile method for the synthesis of glutathione S-conjugates targeting the bacterial potassium efflux system Kef.Titer improvement and pilot-scale production of platensimycin from Streptomyces platensis SB12026.Bacterial cell wall composition and the influence of antibiotics by cell-wall and whole-cell NMR.Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It.Pipeline of Known Chemical Classes of Antibiotics.Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.Targeted Treatment for Bacterial Infections: Prospects for Pathogen-Specific Antibiotics Coupled with Rapid DiagnosticsMutation of the Enterohemorrhagic Escherichia coli Core LPS Biosynthesis Enzyme RfaD Confers Hypersusceptibility to Host Intestinal Innate Immunity In vivoTargeting DXP synthase in human pathogens: enzyme inhibition and antimicrobial activity of butylacetylphosphonate.Antifungal drug development: challenges, unmet clinical needs, and new approaches.Penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus.Renaissance of antibiotics against difficult infections: Focus on oritavancin and new ketolides and quinolones.Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel.Retrospective analysis of natural products provides insights for future discovery trends.Lipidated β-lactamases: from bench to bedside.The applied side of antimicrobial peptide-inducible promoters from Firmicutes bacteria: expression systems and whole-cell biosensors.New Found Hope for Antibiotic Discovery: Lipid II Inhibitors.Genomic and functional techniques to mine the microbiome for novel antimicrobials and antimicrobial resistance genes.Functionalization of nanostructures for antibiotic improvement: an interdisciplinary approach.A bioinspired peptide scaffold with high antibiotic activity and low in vivo toxicityDiversity of nature's assembly lines - recent discoveries in non-ribosomal peptide synthesis.Structure, inhibition, and regulation of essential lipid A enzymes.Rapid access to glycopeptide antibiotic precursor peptides coupled with cytochrome P450-mediated catalysis: towards a biomimetic synthesis of glycopeptide antibiotics.DNA replication proteins as potential targets for antimicrobials in drug-resistant bacterial pathogens.Polishing the tarnished silver bullet: the quest for new antibiotics.Next-generation approaches to understand and combat the antibiotic resistome.
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Prospects for new antibiotics: a molecule-centered perspective.
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article científic
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article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Prospects for new antibiotics: a molecule-centered perspective.
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type
label
Prospects for new antibiotics: a molecule-centered perspective.
@en
prefLabel
Prospects for new antibiotics: a molecule-centered perspective.
@en
P2860
P356
P1476
Prospects for new antibiotics: a molecule-centered perspective.
@en
P2093
Christopher T Walsh
Timothy A Wencewicz
P2860
P2888
P356
10.1038/JA.2013.49
P577
2013-06-12T00:00:00Z
P6179
1042260225