The alpha 1-antitrypsin gene and its mutations. Clinical consequences and strategies for therapy.
about
Expression of the secretory leukoprotease inhibitor gene in epithelial cellsAlpha-1 antitrypsin deficiency is not a rare disease but a disease that is rarely diagnosedAcute-phase protein α1-anti-trypsin: diverting injurious innate and adaptive immune responses from non-authentic threatsDeficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin DeficiencyChallenges and Prospects for Alpha-1 Antitrypsin Deficiency Gene TherapyAnalysis of anti-neutrophil cytoplasmic antibodies (ANCA): frequency and specificity in a sample of 191 homozygous (PiZZ) alpha1-antitrypsin-deficient subjects.Alpha1-antitrypsin deficiency and toxic shock: a Japanese autopsy case.Topical corticosteroids: back to basics.Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.Neutrophil accumulation in the lung in alpha 1-antitrypsin deficiency. Spontaneous release of leukotriene B4 by alveolar macrophagesAlpha 1-antitrypsin deficiency, emphysema, and liver disease. Genetic basis and strategies for therapy.Bronchoalveolar fluid is not a major hindrance to virus-mediated gene therapy in cystic fibrosis.Preclinical evaluation of a recombinant adeno-associated virus vector expressing human alpha-1 antitrypsin made using a recombinant herpes simplex virus production methodCharacterization of the normal alpha 1-antitrypsin allele Vmunich: a variant associated with a unique protein isoelectric focusing patternAlpha 1-antitrypsin Null(isola di procida): an alpha 1-antitrypsin deficiency allele caused by deletion of all alpha 1-antitrypsin coding exonsRecombinant DNA-produced alpha 1-antitrypsin administered by aerosol augments lower respiratory tract antineutrophil elastase defenses in individuals with alpha 1-antitrypsin deficiency.Inhibition by recombinant SLPI and half-SLPI (Asn55-Ala107) of elastase and cathepsin G activities: consequence for neutrophil-platelet cooperation.Health implications of alpha1-antitrypsin deficiency in Sub-Sahara African countries and their emigrants in Europe and the New World.Molecular basis of alpha 1-antitrypsin deficiency and emphysema associated with the alpha 1-antitrypsin Mmineral springs allele.Alpha1-antitrypsin deficiency: a clinical-genetic overview.The design of a new truncated and engineered alpha1-antitrypsin based on theoretical studies: an antiprotease therapeutics for pulmonary diseases.Results from a large targeted screening program for alpha-1-antitrypsin deficiency: 2003 - 2015.Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy.Polymorphisms of α1-antitrypsin and Interleukin-6 genes and the progression of hepatic cirrhosis in patients with a hepatitis C virus infection.Current status of gene therapy for α-1 antitrypsin deficiency.Alpha-1-antitrypsin deficiency: increasing awareness and improving diagnosis.Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease.Gene Therapy for Alpha-1 Antitrypsin Deficiency Lung Disease.Antiproteases as therapeutics to target inflammation in cystic fibrosis.A novel SV40-based vector successfully transduces and expresses an alpha 1-antitrypsin ribozyme in a human hepatoma-derived cell line.Gene transfer to respiratory epithelial cells via the receptor-mediated endocytosis pathway.Pulmonary cell biology.Neutrophil-derived Oxidants and Proteinases as Immunomodulatory Mediators in Inflammation.Pharmacological activity of the C-terminal and N-terminal domains of secretory leukoprotease inhibitor in vitroGene targeted therapeutics for liver disease in alpha-1 antitrypsin deficiencyCigarette Smoking Induces Changes in Airway Epithelial Expression of Genes Associated with Monogenic Lung Disorders.A family study of the variability of pulmonary function in alpha 1-antitrypsin deficiency. Quantitative phenotypes.Rapid screening for alpha1-antitrypsin deficiency in patients with chronic obstructive pulmonary disease using dried blood specimens.Molecular analysis of the heterogeneity among the P-family of alpha-1-antitrypsin alleles.Prognosis and life expectancy on alpha-1-antitrypsin deficiency and chronic liver disease.
P2860
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P2860
The alpha 1-antitrypsin gene and its mutations. Clinical consequences and strategies for therapy.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
The alpha 1-antitrypsin gene a ...... es and strategies for therapy.
@en
type
label
The alpha 1-antitrypsin gene a ...... es and strategies for therapy.
@en
prefLabel
The alpha 1-antitrypsin gene a ...... es and strategies for therapy.
@en
P2093
P356
P1433
P1476
The alpha 1-antitrypsin gene a ...... es and strategies for therapy.
@en
P2093
P304
P356
10.1378/CHEST.95.1.196
P407
P577
1989-01-01T00:00:00Z