Dual control of Yen1 nuclease activity and cellular localization by Cdk and Cdc14 prevents genome instability.
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Hold your horSSEs: controlling structure-selective endonucleases MUS81 and Yen1/GEN1Mechanisms and regulation of mitotic recombination in Saccharomyces cerevisiaeSubstrate preference of Gen endonucleases highlights the importance of branched structures as DNA damage repair intermediates.Functional mapping of yeast genomes by saturated transposition.Top3-Rmi1 DNA single-strand decatenase is integral to the formation and resolution of meiotic recombination intermediates.Recombination between homologous chromosomes induced by unrepaired UV-generated DNA damage requires Mus81p and is suppressed by Mms2pA genomic screen revealing the importance of vesicular trafficking pathways in genome maintenance and protection against genotoxic stress in diploid Saccharomyces cerevisiae cellsDNA REPAIR. Mus81 and converging forks limit the mutagenicity of replication fork breakage.Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1.Resolution of single and double Holliday junction recombination intermediates by GEN1.Dbf4-dependent kinase and the Rtt107 scaffold promote Mus81-Mms4 resolvase activation during mitosisHolliday junction resolution: regulation in space and time.Cdc14 phosphatase: warning, no delay allowed for chromosome segregation!Resolution of Recombination Intermediates: Mechanisms and Regulation.An Overview of the Molecular Mechanisms of Recombinational DNA Repair.Pervasive and essential roles of the Top3-Rmi1 decatenase orchestrate recombination and facilitate chromosome segregation in meiosis.Transcription-replication conflicts at chromosomal fragile sites-consequences in M phase and beyond.The control of DNA repair by the cell cycle.Cell cycle-dependent control of homologous recombination.Structural and Mechanistic Analysis of the Slx1-Slx4 EndonucleaseStabilization of the metaphase spindle by Cdc14 is required for recombinational DNA repair.Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage.Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates.The Slx4-Dpb11 scaffold complex: coordinating the response to replication fork stalling in S-phase and the subsequent mitosis.Spatial control of the GEN1 Holliday junction resolvase ensures genome stability.GEN1 promotes Holliday junction resolution by a coordinated nick and counter-nick mechanism.Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2.Resolvase OsGEN1 Mediates DNA Repair by Homologous Recombination.GSK-3β Homolog Rim11 and the Histone Deacetylase Complex Ume6-Sin3-Rpd3 Are Involved in Replication Stress Response Caused by Defects in Dna2.Main steps in DNA double-strand break repair: an introduction to homologous recombination and related processes.DNA Damage Tolerance Pathway Choice Through Uls1 Modulation of Srs2 SUMOylation in Saccharomyces cerevisiae.The nucleolytic resolution of recombination intermediates in yeast mitotic cells.Mus81-Mms4 and Yen1 resolve a novel anaphase bridge formed by noncanonical Holliday junctions.
P2860
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P2860
Dual control of Yen1 nuclease activity and cellular localization by Cdk and Cdc14 prevents genome instability.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Dual control of Yen1 nuclease ...... 4 prevents genome instability.
@en
type
label
Dual control of Yen1 nuclease ...... 4 prevents genome instability.
@en
prefLabel
Dual control of Yen1 nuclease ...... 4 prevents genome instability.
@en
P2860
P50
P1433
P1476
Dual control of Yen1 nuclease ...... 4 prevents genome instability.
@en
P2860
P304
P356
10.1016/J.MOLCEL.2014.02.011
P577
2014-03-13T00:00:00Z