NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway. - sprookjes - yvandenbroek - TriplyDB

NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway.

NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway.

http://www.wikidata.org/entity/Q39889099

about

Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine Sirtuin deacylases: a molecular link between metabolism and immunity Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats Congenital neutropenia: diagnosis, molecular bases and patient management.Increased plasma nicotinamide phosphoribosyltransferase is associated with a hyperproliferative phenotype and restrains disease progression in MPN-associated myelofibrosis.A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis.miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia.The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways."Clocks" in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging Compartmentation of NAD+-dependent signalling.Prognostic value of serum nicotinamide phosphoribosyltransferase in patients with bladder cancer.EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition Cyclic AMP responsive element binding proteins are involved in 'emergency' granulopoiesis through the upregulation of CCAAT/enhancer binding protein β Inhibition of the NAD-dependent protein deacetylase SIRT2 induces granulocytic differentiation in human leukemia cells.C/EBPε mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice.Leucocytes are a major source of circulating nicotinamide phosphoribosyltransferase (NAMPT)/pre-B cell colony (PBEF)/visfatin linking obesity and inflammation in humans.Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells Dissecting systemic control of metabolism and aging in the NAD World: the importance of SIRT1 and NAMPT-mediated NAD biosynthesis.Nicotinamide exacerbates hypoxemia in ventilator-induced lung injury independent of neutrophil infiltration.Nicotinamide Phosphoribosyltransferase in Human Diseases.Pre-B-cell colony-enhancing factor exerts a neuronal protection through its enzymatic activity and the reduction of mitochondrial dysfunction in in vitro ischemic models.Pre-clinical efficacy of combined therapy with novel β-catenin antagonist BC2059 and histone deacetylase inhibitor against AML cells SIRT1 is dispensable for function of hematopoietic stem cells in adult mice.Non-steady-state hematopoiesis regulated by the C/EBPβ transcription factor.Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition.Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases.SIRT1 and energy metabolism.An NAD(+) biosynthetic pathway enzyme functions cell non-autonomously in C. elegans development.Circadian rhythms and cancer.PBEF/NAMPT/visfatin: a promising drug target for treating rheumatoid arthritis?G-CSF: filgrastim, lenograstim and biosimilars.Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology.Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is a tumoural cytokine released from melanoma.Nicotinamide overcomes pluripotency deficits and reprogramming barriers.Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells.

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NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway.

http://www.wikidata.org/entity/Q39889099

description

2009 nî lūn-bûn

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2009年学术文章

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2009年學術文章

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2009年學術文章

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2009年學術文章

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name

NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD

@nl

NAMPT is essential for the G-C ...... )-sirtuin-1-dependent pathway.

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type

label

NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD

@nl

NAMPT is essential for the G-C ...... )-sirtuin-1-dependent pathway.

@en

prefLabel

NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD

@nl

NAMPT is essential for the G-C ...... )-sirtuin-1-dependent pathway.

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Nature Medicine

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NAMPT is essential for the G-C ...... )-sirtuin-1-dependent pathway.

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Annette Müller Brechlin

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Basant Kumar Thakur

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Dan Lan

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Fei Wang

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Gunnar Cario

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Gustav Meyer

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Julia Skokowa

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Karl Welte

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Kshama Gupta

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Lars Hinrichsen

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P2860

Negative control of p53 by Sir2alpha promotes cell survival under stress

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme

LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia

Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor

The Sir2 family of protein deacetylases

HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease)

NAD metabolism and sirtuins: metabolic regulation of protein deacetylation in stress and toxicity

SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex

Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy

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151-158

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10.1038/NM.1913

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2

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15

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Matthias Gaestel

Martin Stanulla

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2009-02-01T00:00:00Z

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1003599497

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19182797

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