Mutant p53 cooperates with ETS and selectively up-regulates human MDR1 not MRP1. - sprookjes - yvandenbroek - TriplyDB

Mutant p53 cooperates with ETS and selectively up-regulates human MDR1 not MRP1.

Mutant p53 cooperates with ETS and selectively up-regulates human MDR1 not MRP1.

http://www.wikidata.org/entity/Q40788757

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The biology of the Ets1 proto-oncogene Mutant p53 attenuates the SMAD-dependent transforming growth factor beta1 (TGF-beta1) signaling pathway by repressing the expression of TGF-beta receptor type II Mutant p53 proteins bind DNA in a DNA structure-selective mode Mutant p53 and ETS2, a Tale of Reciprocity Involvement of p53 in the repair of DNA double strand breaks: multifaceted Roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ)Individual and combined effects of DNA methylation and copy number alterations on miRNA expression in breast tumors Overrepresentation of transcription factor families in the genesets underlying breast cancer subtypes A critical dose of doxorubicin is required to alter the gene expression profiles in MCF-7 cells acquiring multidrug resistance Ets1 is an effector of protein kinase Calpha in cancer cells.Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers.Antiproliferative and proapoptotic activity of GUT-70 mediated through potent inhibition of Hsp90 in mantle cell lymphoma Prognostic significance of multidrug-resistance protein (MDR-1) in renal clear cell carcinomas: a five year follow-up analysis.Ets1 induces dysplastic changes when expressed in terminally-differentiating squamous epidermal cells Degradation of mutant p53H175 protein by Zn(II) through autophagy.Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis mediated by mutant p53 in Hepatocellular Carcinoma.Mutant p53-induced up-regulation of mitogen-activated protein kinase kinase 3 contributes to gain of function Direct regulation of BCL-2 by FLI-1 is involved in the survival of FLI-1-transformed erythroblasts Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells.Multidrug resistance 1 gene (P-glycoprotein 170): an important determinant in gastrointestinal disease?Molecular pathways: regulation and therapeutic implications of multidrug resistance A novel p53 phosphorylation site within the MDM2 ubiquitination signal: II. a model in which phosphorylation at SER269 induces a mutant conformation to p53 Overcoming drug resistance by regulating nuclear receptors.DNA damage-induced ephrin-B2 reverse signaling promotes chemoresistance and drives EMT in colorectal carcinoma harboring mutant p53 Cancer chemoresistance: the relationship between p53 and multidrug transporters.microRNAs: short non-coding bullets of gain of function mutant p53 proteins.Upregulation of the mitochondrial transport protein, Tim50, by mutant p53 contributes to cell growth and chemoresistance Comparison of effects of p53 null and gain-of-function mutations on salivary tumors in MMTV-Hras transgenic mice.Forced expression of heat shock protein 27 (Hsp27) reverses P-glycoprotein (ABCB1)-mediated drug efflux and MDR1 gene expression in Adriamycin-resistant human breast cancer cells A mutant p53/let-7i-axis-regulated gene network drives cell migration, invasion and metastasis.Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer.Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities.MYCN enhances P-gp/MDR1 gene expression in the human metastatic neuroblastoma IGR-N-91 model.Cancer-derived p53 mutants suppress p53-target gene expression--potential mechanism for gain of function of mutant p53.Sensitization of chemo-resistant human chronic myeloid leukemia stem-like cells to Hsp90 inhibitor by SIRT1 inhibition.Mutant p53 cooperates with ETS2 to promote etoposide resistance.MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function Mutant p53: one name, many proteins.Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF).Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1.

P2860

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P2860

Mutant p53 cooperates with ETS and selectively up-regulates human MDR1 not MRP1.

http://www.wikidata.org/entity/Q40788757

description

2001 nî lūn-bûn

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2001年の論文

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年學術文章

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2001年學術文章

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2001年學術文章

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name

Mutant p53 cooperates with ETS and selectively up-regulates human MDR1 not MRP1.

@en

type

label

Mutant p53 cooperates with ETS and selectively up-regulates human MDR1 not MRP1.

@en

prefLabel

Mutant p53 cooperates with ETS and selectively up-regulates human MDR1 not MRP1.

@en

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Journal of Biological Chemistry

P1476

Mutant p53 cooperates with ETS and selectively up-regulates human MDR1 not MRP1.

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P2093

A Gandhi

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D Sun

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G P Zambetti

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J D Schuetz

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J Grenet

http://www.w3.org/2001/XMLSchema#string

J Sampath

http://www.w3.org/2001/XMLSchema#string

L H Shapiro

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Q Wang

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V J Kidd

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P2860

Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression

The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21) fusion protein

c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation

MBP1: a novel mutant p53-specific protein partner with oncogenic properties

Transcriptional regulation of the MDR1 gene by histone acetyltransferase and deacetylase is mediated by NF-Y.

Structural, mechanistic and clinical aspects of MRP1.

Multiple physiological functions for multidrug transporter P-glycoprotein?

A family of drug transporters: the multidrug resistance-associated proteins.

Multidrug resistance: molecular mechanisms and clinical relevance.

Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein

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39359-39367

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10.1074/JBC.M103429200

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42

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276

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11483599

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