Replacement of the CysA7-CysB7 disulfide bond with a 1,2,3-triazole linker causes unfolding in insulin glargine.
about
"Pruning of biomolecules and natural products (PBNP)": an innovative paradigm in drug discovery.Total Chemical Synthesis of an Intra-A-Chain Cystathionine Human Insulin Analogue with Enhanced Thermal Stability.HIV-1 Frameshift RNA-Targeted Triazoles Inhibit Propagation of Replication-Competent and Multi-Drug-Resistant HIV in Human Cells.Chemically synthesized dicarba H2 relaxin analogues retain strong RXFP1 receptor activity but show an unexpected loss of in vitro serum stability.Rational steering of insulin binding specificity by intra-chain chemical crosslinkingDisulfide Bond Mimetics: Strategies and Challenges.Urotensin-II peptidomimetic incorporating a non-reducible 1,5-triazole disulfide bond reveals a pseudo-irreversible covalent binding mechanism to the urotensin G-protein coupled receptor.
P2860
Q38475630-78643B2E-E747-435A-9E16-0D2DB6CF1946Q39120979-16E444E8-465D-4773-B5F4-B49A11480AEBQ40225647-5EEEFC69-A2AE-43EB-A5F1-5443E9DEDC70Q40541284-879CB6CF-A16E-4CA0-B9B5-108B50EFC575Q41960756-920DF156-636B-4FD1-BD31-C94C9C58365DQ47875052-B5F5DDC2-65BF-48F7-97FB-3C4B3A77A7B3Q50992476-86BD6AE6-78FB-44DC-AC5E-1920ED19FE8C
P2860
Replacement of the CysA7-CysB7 disulfide bond with a 1,2,3-triazole linker causes unfolding in insulin glargine.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Replacement of the CysA7-CysB7 ...... unfolding in insulin glargine.
@en
type
label
Replacement of the CysA7-CysB7 ...... unfolding in insulin glargine.
@en
prefLabel
Replacement of the CysA7-CysB7 ...... unfolding in insulin glargine.
@en
P2093
P2860
P356
P1476
Replacement of the CysA7-CysB7 ...... unfolding in insulin glargine.
@en
P2093
Geoffrey M Williams
Kathryn Lee
P2860
P304
P356
10.1039/C5OB00160A
P577
2015-04-01T00:00:00Z