about
Crystal structure of a substrate complex of myo-inositol oxygenase, a di-iron oxygenase with a key role in inositol metabolismPreptin derived from proinsulin-like growth factor II (proIGF-II) is secreted from pancreatic islet beta-cells and enhances insulin secretionIncreased expression and activation of c-Jun contributes to human amylin-induced apoptosis in pancreatic islet beta-cellsTetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic miceNucleotide sequence of a cDNA for canine amylin.Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice.The aggregation potential of human amylin determines its cytotoxicity towards islet beta-cells.Direct visualisation of peptide hormones in cultured pancreatic islet alpha- and beta-cells by intact-cell mass spectrometry.Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activitiesA simple and rapid method for identifying and semi-quantifying peptide hormones in isolated pancreatic islets by direct-tissue matrix-assisted laser desorption ionization time-of-flight mass spectrometry.Evidence that multiple defects in lipid regulation occur before hyperglycemia during the prodrome of type-2 diabetes.Atomic force microscopy reveals defects within mica supported lipid bilayers induced by the amyloidogenic human amylin peptide.Adiponectin induces A20 expression in adipose tissue to confer metabolic benefit.Complex formation equilibria of Cu2+ and Zn2+ with Irbesartan and Losartan.Treatment with a copper-selective chelator causes substantive improvement in cardiac function of diabetic rats with left-ventricular impairmentAltered calcium homeostasis does not explain the contractile deficit of diabetic cardiomyopathy.Graded perturbations of metabolism in multiple regions of human brain in Alzheimer's disease: Snapshot of a pervasive metabolic disorderElevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer's disease: metabolic basis for dementia.Harmine Induces Adipocyte Thermogenesis through RAC1-MEK-ERK-CHD4 Axis.Transcriptomic analysis of the cardiac left ventricle in a rodent model of diabetic cardiomyopathy: molecular snapshot of a severe myocardial disease.Using mass spectrometry to detect, differentiate, and semiquantitate closely related peptide hormones in complex milieu: measurement of IGF-II and vesiculin.Synthesis of stable isotope-labelled monolysyl advanced glycation endproducts.Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice.Thiol reducing compounds prevent human amylin-evoked cytotoxicity.Metabolic Dysfunction Is Restricted to the Sciatic Nerve in Experimental Diabetic Neuropathy.Chronic treatment with growth hormone stimulates adiponectin gene expression in 3T3-L1 adipocytes.Deficient copper concentrations in dried-defatted hepatic tissue from ob/ob mice: A potential model for study of defective copper regulation in metabolic liver disease.Fibrillogenic amylin evokes islet beta-cell apoptosis through linked activation of a caspase cascade and JNK1.Alteration in phosphorylation of P20 is associated with insulin resistance.Induction of apoptosis by human amylin in RINm5F islet beta-cells is associated with enhanced expression of p53 and p21WAF1/CIP1.Diabetes-induced alterations in tissue collagen and carboxymethyllysine in rat kidneys: Association with increased collagen-degrading proteinases and amelioration by Cu(II)-selective chelation.Replacement of the CysA7-CysB7 disulfide bond with a 1,2,3-triazole linker causes unfolding in insulin glargine.Suppression by polycyclic compounds of the conversion of human amylin into insoluble amyloid.Thalamic amplification of sensory input in experimental diabetes.Pharmacokinetics, pharmacodynamics, and metabolism of triethylenetetramine in healthy human participants: an open-label trial.Effects of calcitonin, amylin, and calcitonin gene-related peptide on osteoclast development.Complex formation equilibria of Cu(II) and Zn(II) with triethylenetetramine and its mono- and di-acetyl metabolites.Reversal of diabetes-evoked changes in mitochondrial protein expression of cardiac left ventricle by treatment with a copper(II)-selective chelator.Preptin, another peptide product of the pancreatic beta-cell, is osteogenic in vitro and in vivo.α-Calcitonin gene related peptide (α-CGRP) mediated lipid mobilization in 3T3-L1 adipocytes.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Garth Cooper
@ast
Garth Cooper
@en
Garth Cooper
@es
Garth Cooper
@nl
Garth Cooper
@sl
type
label
Garth Cooper
@ast
Garth Cooper
@en
Garth Cooper
@es
Garth Cooper
@nl
Garth Cooper
@sl
prefLabel
Garth Cooper
@ast
Garth Cooper
@en
Garth Cooper
@es
Garth Cooper
@nl
Garth Cooper
@sl
P1053
I-3201-2015
P106
P21
P31
P3829
P496
0000-0001-5241-3163