Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance. - sprookjes - yvandenbroek - TriplyDB

Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance.

Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance.

http://www.wikidata.org/entity/Q41715654

about

Naïve T Cell Homeostasis Regulated by Stress Responses and TCR Signaling Lower Affinity T Cells are Critical Components and Active Participants of the Immune Response The role of T cell receptor signaling thresholds in guiding T cell fate decisions Indoctrinating T cells to attack pathogens through homeschooling Distinct Mechanisms Regulate Lck Spatial Organization in Activated T Cells.A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli.Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation T Cells Integrate Local and Global Cues to Discriminate between Structurally Similar Antigens Small molecule inhibition of Csk alters affinity recognition by T cells.Revealing the TCR bias for MHC molecules Functional evidence for TCR-intrinsic specificity for MHCII.Sonic Hedgehog regulates thymic epithelial cell differentiation Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets.Hedgehog Signalling in the Embryonic Mouse Thymus Phosphorylation of a Tyrosine Residue on Zap70 by Lck and Its Subsequent Binding via an SH2 Domain May Be a Key Gatekeeper of T Cell Receptor Signaling In Vivo.Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose.Codification of bidentate pMHC interaction with TCR and its co-receptor.Suboptimal T-cell receptor signaling compromises protein translation, ribosome biogenesis, and proliferation of mouse CD8 T cells.Enhanced Detection of Antigen-Specific CD4+ T Cells Using Altered Peptide Flanking Residue Peptide-MHC Class II Multimers.Generation of Peptides That Promote Positive Selection in the Thymus.Targeted loss of SHP1 in murine thymocytes dampens TCR signaling late in selection Opposing effects of actin signaling and LFA-1 on establishing the affinity threshold for inducing effector T-cell responses in mice.The CD4 and CD3δε Cytosolic Juxtamembrane Regions Are Proximal within a Compact TCR-CD3-pMHC-CD4 Macrocomplex.Critical biological parameters modulate affinity as a determinant of function in T-cell receptor gene-modified T-cells.The cellular environment regulates in situ kinetics of T-cell receptor interaction with peptide major histocompatibility complex.Immune Tolerance Maintained by Cooperative Interactions between T Cells and Antigen Presenting Cells Shapes a Diverse TCR Repertoire.Force and affinity in ligand discrimination by the TCR.T cell receptor dwell times control the kinase activity of Zap70.Monoclonal regulatory T cells provide insights into T cell suppression.A unifying mathematical framework for experimental TCR-pMHC kinetic constants.Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope.Src-family kinases negatively regulate NFAT signaling in resting human T cells.Encoding optical control in LCK kinase to quantitatively investigate its activity in live cells.Receptor-mediated cell mechanosensing.Emerging Concepts in TCR Specificity: Rationalizing and (Maybe) Predicting Outcomes.Discrete TCR Binding Kinetics Control Invariant NKT Cell Selection and Central Priming.Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex.Strong TCR-mediated signals suppress integrated stress responses induced by KDELR1 deficiency in naive T cells.Timing and duration of MHC I positive selection signals are adjusted in the thymus to prevent lineage errors.

P2860

Q26770670-FF0AF9AF-1E25-4948-825F-F4B01F33B391 Q26781296-F1C32069-825F-407E-9CDC-810A632C5978 Q26999436-56735BD3-E911-40E8-9142-3EEA47821673 Q27012849-BC2B36FF-8C18-4253-AE08-D25EBF62D27E Q27329458-B49264BE-BE2A-4F81-AE68-46701EE94095 Q33852715-DD947FAD-60E6-4A51-90FB-F8DA14983B5C Q34383687-CDF597E4-C7DD-44E4-98C9-66B979FA4314 Q35893938-4AFD76F4-3D25-4A57-A3B4-1B15F180D7B6 Q36056553-CE9F7E3A-EA3A-4FC6-AE98-7A8252667456 Q36710540-ECA73D5D-D78B-4822-A774-5D5DA5B4D24E Q36710561-23D7D321-759D-4E77-B2B9-E1DB6D949877 Q36715524-3EBF5BC6-3056-4375-99E9-CF5A4124B05D Q36931097-B630EA7C-5FFA-471A-97DA-0FDCAB0AE3BA Q37072024-3CBF910E-0BFF-47B3-98F5-A775450D45D9 Q37156603-A3764260-1520-4BD8-93A6-6C3447ACF688 Q37224164-542065C3-DA81-4303-86D9-09495286514E Q37379865-9209D824-7A4D-46E1-9168-E842E81D7B45 Q38394531-8FA8FA9A-C94E-45A0-BC1B-353190CC0A4F Q38684447-7B250FBB-73B4-4F7A-8A4C-6FF52EC1E9D3 Q38820674-918DFBF6-84C7-438E-BD20-9CC1D1C1499C Q39164395-46D2BF68-2957-45F0-AE49-1BE6E524108F Q39647156-4EEFC8E5-83C9-4503-8415-9973F263FA78 Q39759757-A9C8FB4A-DBA3-4829-AB54-F6C879CC1B3B Q39763185-25F7FDF2-EEA8-4553-BCCB-25ADFA7B13E4 Q40151758-F32BC46A-D0C3-4F3D-8DC7-BBCFDC7CA136 Q40972761-54C07774-C800-4C6B-AF65-3681E8959E7C Q41036936-45851B26-A855-4C35-89AB-E305312146CF Q41681613-5E03B5CB-568A-427C-A9CD-9B907E50ACC7 Q41809472-C84E73C4-E022-4B4F-B59E-B99289BEE5FD Q42138753-B56FF5DC-786A-4BB9-AE9A-B1DCF6B9B38B Q42290491-A44CC30C-80F9-4ADA-9565-6A358B073B9E Q47100829-6C5FA18A-354F-4EA2-8621-503DEDD365F2 Q47165489-F2676ED3-9146-457A-931C-3A9FF72ACD65 Q47588671-60572351-4527-4555-8EDE-D793134823BF Q47625174-7E9EE87F-8FB6-485E-B736-C4CF336F97F1 Q47782025-0E09501B-40A1-4547-8E25-E654F76EFD00 Q48261213-A2BCCF68-447A-448E-9D36-83FF7DB56EE6 Q49547293-457A677A-F708-440C-A9EE-147032876802 Q50282444-3BECCD8F-4F37-440C-A593-0BEA295C9733 Q51461656-174A3238-D061-4120-91D6-BF1BB4828C73

P2860

Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance.

http://www.wikidata.org/entity/Q41715654

description

2014 nî lūn-bûn

@nan

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

2014年论文

@zh

2014年论文

@zh-cn

name

Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance.

@en

type

label

Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance.

@en

prefLabel

Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance.

@en

P1433

Q41715654-F741BD77-3EEF-4272-94EA-0D3B83B67274

P1476

Q41715654-8DAFDED1-B7D3-4F28-B30B-D31C3A05071D

P2093

Q41715654-0D94CA73-CDC1-4234-AF46-5AB42E289921

Q41715654-13D04C42-4F18-4B05-8BE6-5CC714D58BD8

Q41715654-1E24190D-0786-4594-8FA6-4E7B4E616CDE

Q41715654-2457CCE7-E8A9-4969-95A4-4FBC68076AD9

Q41715654-29198314-AC1F-42D8-975D-2AB22ED05715

Q41715654-4D27693D-13AA-4AD0-8684-32A13D7AC9B8

Q41715654-7F0FC960-C1E0-4260-8482-432634B4C518

Q41715654-8B8E2AF9-1C00-45CD-81AB-E25077AAE75D

Q41715654-8F96DC49-4983-48AA-9211-79844B1E9680

Q41715654-B4FCE7D5-3D0A-4BDE-AE07-FF22BDC30725

P2860

Q41715654-0BBD4D84-B6DE-4991-A5FF-26E336598C3B

Q41715654-187B7885-287E-44A2-A1C1-79618C4FAA4D

Q41715654-2C6F8AE8-A92F-41CF-B10C-F3D8C8DE1F6F

Q41715654-3596A818-82ED-491D-ACEA-2E0ECEA69EE0

Q41715654-3AE272BC-1C40-47D2-BAC6-36DC12A4CAAD

Q41715654-3BEC79F9-3E41-4725-81A5-9DF728779BB3

Q41715654-3FAD7AF7-4E6D-47CC-81DF-283FE314BA92

Q41715654-4066F772-D7FC-447C-86E5-9C3CECC5FCE8

Q41715654-436AC3E7-D9B2-4489-BBF9-D399C1DBED6F

Q41715654-443506E5-9D96-4567-A266-8A45A94A5F96

P304

Q41715654-318A4C63-D634-4C60-BBA1-F90FD69CC566

P31

Q41715654-F249BE7D-024D-4330-8BD1-AAB601218767

P356

Q41715654-6410476B-E29A-41B1-B814-D7095489B53D

P407

Q41715654-2D46F9E4-6B3D-4467-AD71-AD05688B26F8

P433

Q41715654-7F9802ED-741B-4F85-8EE4-81F74489C36F

P478

Q41715654-CD9304C8-D55E-4EB0-8670-95ABE0AD014E

P50

Q41715654-39987850-4192-417D-B912-5F0C5E89C2BF

Q41715654-409D0D15-58BE-42F7-AC58-59893D036F45

Q41715654-5A4A0FCB-50FB-4989-8502-6795DB475F34

P577

Q41715654-99705A7A-0DC6-4A0E-81C0-6F8B9C7CCCA8

P5875

Q41715654-22A63174-0666-478E-9C3F-FBE2A21217D1

P698

Q41715654-9BBE9AA9-9BBC-4D0A-AFBA-62CE42CAE382

P932

Q41715654-2AD7A505-997E-4AFC-8B46-DA764E6C0BF8

P356

J.CELL.2014.08.042

P1433

P1476

Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance.

@en

P2093

Anna Bulek

http://www.w3.org/2001/XMLSchema#string

Arup K Chakraborty

http://www.w3.org/2001/XMLSchema#string

Arvind S Prabhakar

http://www.w3.org/2001/XMLSchema#string

Barbara Hausmann

http://www.w3.org/2001/XMLSchema#string

Carolyn G King

http://www.w3.org/2001/XMLSchema#string

Celine Osswald

http://www.w3.org/2001/XMLSchema#string

Dieter Naeher

http://www.w3.org/2001/XMLSchema#string

Ed Palmer

http://www.w3.org/2001/XMLSchema#string

Eric S Huseby

http://www.w3.org/2001/XMLSchema#string

Marina Beaufils-Hugot

http://www.w3.org/2001/XMLSchema#string

P2860

Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity

T cell activation

Lck availability during thymic selection determines the recognition specificity of the T cell repertoire

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagement

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

Two-stage cooperative T cell receptor-peptide major histocompatibility complex-CD8 trimolecular interactions amplify antigen discrimination

T cell receptor antagonist peptides induce positive selection

Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation.

Distinct temporal patterns of T cell receptor signaling during positive versus negative selection in situ

P304

333-345

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.CELL.2014.08.042

http://www.w3.org/2001/XMLSchema#string

P407

P433

2

http://www.w3.org/2001/XMLSchema#string

P478

159

http://www.w3.org/2001/XMLSchema#string

P50

Andrew K Sewell

Ondrej Stepanek

P577

2014-10-02T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

266623373

http://www.w3.org/2001/XMLSchema#string

P698

25284152

http://www.w3.org/2001/XMLSchema#string

P932

4304671

http://www.w3.org/2001/XMLSchema#string