Lck availability during thymic selection determines the recognition specificity of the T cell repertoire
about
The Timing of T Cell Priming and CyclingCoevolution of T-cell receptors with MHC and non-MHC ligandsDistinct Mechanisms Regulate Lck Spatial Organization in Activated T Cells.Effect of CDR3 Sequences and Distal V Gene Residues in Regulating TCR-MHC Contacts and Ligand SpecificityProteomic Signatures of ThymomasT cell receptor bias for MHC: co-evolution or co-receptors?Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.Generation of individual diversity: a too neglected fundamental property of adaptive immune system.A novel T cell subset with trans-rearranged Vγ-Cβ TCRs shows Vβ expression is dispensable for lineage choice and MHC restrictionThe role of tyrosine kinases in systemic lupus erythematosus and their potential as therapeutic targets.Regulation of T cell development by c-Cbl: essential role of Lck.T Cell Receptor Engineering and Analysis Using the Yeast Display Platform.Lymphocyte-specific protein tyrosine kinase (Lck) interacts with CR6-interacting factor 1 (CRIF1) in mitochondria to repress oxidative phosphorylation.Nuclear lymphocyte-specific protein tyrosine kinase and its interaction with CR6-interacting factor 1 promote the survival of human leukemic T cells.Functional evidence for TCR-intrinsic specificity for MHCII.TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8(+) T cells.Hydrophobic CDR3 residues promote the development of self-reactive T cells.Genetic variation in MHC proteins is associated with T cell receptor expression biasesClass II major histocompatibility complex mutant mice to study the germ-line bias of T-cell antigen receptorsαβ T cell receptor germline CDR regions moderate contact with MHC ligands and regulate peptide cross-reactivityPrimate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms.Strict Major Histocompatibility Complex Molecule Class-Specific Binding by Co-Receptors Enforces MHC-Restricted αβ TCR Recognition during T Lineage Subset CommitmentLymphocyte repertoire selection and intracellular self/non-self-discrimination: historical overview.The T cell antigen receptor: the Swiss army knife of the immune system.An old Twist in HLA-A: CDR3α Hook up at an R65-joint.Human TCR-MHC coevolution after divergence from mice includes increased nontemplate-encoded CDR3 diversity.T cell receptor repertoires of mice and humans are clustered in similarity networks around conserved public CDR3 sequencesThoughts on Positive Selection in Thymus.Role of the MHC restriction during maturation of antigen-specific human T cells in the thymus.T-cell development is regulated by the coordinated function of proximal and distal Lck promoters active at different developmental stages.Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance.Dietary protein sources differentially affect microbiota, mTOR activity and transcription of mTOR signaling pathways in the small intestine.N-glycosylation bidirectionally extends the boundaries of thymocyte positive selection by decoupling Lck from Ca²⁺ signaling.Venkatesh et al. reply.Impact of lipid rafts on the T-cell-receptor and peptide-major-histocompatibility-complex interactions under different measurement conditions.Timing and duration of MHC I positive selection signals are adjusted in the thymus to prevent lineage errors.The immunological synapse
P2860
Q26776548-83FF1DA0-A0FE-40AE-92F2-D5FAC7E158F7Q26797242-C8333036-BD52-45B8-934E-8568628BA35AQ27329458-95571BB9-7D23-4C65-8E74-39F76A0D9E38Q27683690-6627EB60-6B08-49B5-9798-EADE55080914Q28553440-ABA16A75-114E-43C6-8A3B-1E2660EEF04AQ29037684-F9358A87-F067-45C5-A2F2-AF7EF14B5A36Q30583549-FB58733D-445E-434E-BF0B-519C9AC90A17Q33633789-B401447D-F60A-458D-8A1D-882E23FDBC76Q34389870-B3AD1A67-EC18-4EF5-8C65-21EC1739336AQ34597949-71AB87C5-204A-4C58-8B9C-44388595457EQ35524069-A9CADDE6-EFCC-4F38-86AB-1DC4D1769C26Q35659205-524D4EA4-9292-4A21-B025-E9E0F9886AAAQ35713802-A654C013-5560-43DE-B05C-BED591E3056CQ35794308-244E407A-49A6-425A-A55E-6759C2A7F451Q36710561-47DB88A3-E9B0-41AD-B531-C484362E8336Q36737068-4EADCFEA-07D8-42EE-9870-7AEC21BB7111Q37114342-A7B78EB2-9B77-4238-89B2-4A36E9526E7CQ37231156-67ADE8FF-BBAA-4B30-AFB3-AD36DA13B0C2Q37281369-1D2B3DE5-F8C0-492F-A955-03C941904BC0Q37360117-8B0784C9-EBF9-43E2-A241-64F0F71E1C12Q37532593-AF9C8E23-30C1-43C8-8A68-0D2B5C0438B9Q38169708-3DB5EA75-F80C-405E-81CA-DF1164E55606Q38266751-970463C1-D9F7-48F7-B202-08390C51805FQ38370910-EAE91140-9CCB-43C0-972B-10F8158ADCF4Q38527828-30B3F1DF-F7A3-4E42-AE80-17BA1CB2176CQ38611225-A6E75914-258C-4880-A2D2-FB54B42A40ECQ38668242-A5DD8584-E938-4D94-B225-500C90D68AC2Q38718998-4BD2F0C4-9821-4971-A083-0FA0FAB8D733Q38814475-E4CBDE28-CA77-4EB3-B68C-5BC76FE0C465Q41641077-18F200FD-E5CC-4DCF-9B40-6F1E176745F1Q41715654-51D714E0-98B1-42D2-942A-85EE89687A5DQ46259551-C5833AF3-FA24-44A8-A643-453070D3B451Q46749545-64A0230A-5A3E-476D-93A3-F14B1CE7519FQ50649899-946EBB11-39C7-475B-A96E-B74AE1B40652Q51001267-015E6C3E-3D80-408A-9E05-8CE267379059Q51461656-9B0138F7-9D65-49A0-856A-32CACC8F2BEBQ57961866-D9272050-A0E8-4208-9448-4869C34F693D
P2860
Lck availability during thymic selection determines the recognition specificity of the T cell repertoire
description
2013 nî lūn-bûn
@nan
2013 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Lck availability during thymic ...... icity of the T cell repertoire
@ast
Lck availability during thymic ...... icity of the T cell repertoire
@en
Lck availability during thymic ...... icity of the T cell repertoire
@nl
type
label
Lck availability during thymic ...... icity of the T cell repertoire
@ast
Lck availability during thymic ...... icity of the T cell repertoire
@en
Lck availability during thymic ...... icity of the T cell repertoire
@nl
prefLabel
Lck availability during thymic ...... icity of the T cell repertoire
@ast
Lck availability during thymic ...... icity of the T cell repertoire
@en
Lck availability during thymic ...... icity of the T cell repertoire
@nl
P2093
P2860
P921
P3181
P1433
P1476
Lck availability during thymic ...... icity of the T cell repertoire
@en
P2093
Alfred Singer
Anastasia N Tikhonova
Anthony Adams
Cécile Le Saout
François Van Laethem
Leonid A Pobezinsky
Lionel Feigenbaum
Motoko Y Kimura
Susan O Sharrow
Terry I Guinter
P2860
P304
P3181
P356
10.1016/J.CELL.2013.08.009
P407
P577
2013-09-01T00:00:00Z