Critical role of acrolein in secondary injury following ex vivo spinal cord trauma. - sprookjes - yvandenbroek - TriplyDB

Critical role of acrolein in secondary injury following ex vivo spinal cord trauma.

Critical role of acrolein in secondary injury following ex vivo spinal cord trauma.

http://www.wikidata.org/entity/Q41879134

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Anti-acrolein treatment improves behavioral outcome and alleviates myelin damage in experimental autoimmune encephalomyelitis mouse Oxidative stress, DNA damage, and the telomeric complex as therapeutic targets in acute neurodegeneration Molecular mechanism of acrylamide neurotoxicity: lessons learned from organic chemistry Molecular mechanisms of acrolein-mediated myelin destruction in CNS trauma and disease Acrolein-mediated conduction loss is partially restored by K⁺ channel blockers Reactions of electrophiles with nucleophilic thiolate sites: relevance to pathophysiological mechanisms and remediation Acrolein involvement in sensory and behavioral hypersensitivity following spinal cord injury in the rat Morroniside protects SK-N-SH human neuroblastoma cells against H2O2-induced damage.Structural and biochemical abnormalities in the absence of acute deficits in mild primary blast-induced head trauma.Antioxidant therapies in traumatic brain and spinal cord injury Acrolein as a novel therapeutic target for motor and sensory deficits in spinal cord injury Lipid peroxidation-derived reactive aldehydes directly and differentially impair spinal cord and brain mitochondrial function.Integrative emphases on intimate, intrinsic propensity/pathological processes--causes of self recovery limits and also, subtle related targets for neuroprotectionl pleiotropicity/multimodal actions, by accessible therapeutic approaches--in spinal co Antioxidant therapies for acute spinal cord injury.Neuroprotective role of hydralazine in rat spinal cord injury-attenuation of acrolein-mediated damage.Acrolein detection: potential theranostic utility in multiple sclerosis and spinal cord injury.Nanomedicine strategies for treatment of secondary spinal cord injury.Nanomedicine for treating spinal cord injury.Acute systemic accumulation of acrolein in mice by inhalation at a concentration similar to that in cigarette smoke Lipid peroxidation in brain or spinal cord mitochondria after injury An overview of pharmacological approaches for management and repair of spinal cord injuries.Acrolein-mediated injury in nervous system trauma and diseases Acrolein contributes to TRPA1 up-regulation in peripheral and central sensory hypersensitivity following spinal cord injury.Unilateral microinjection of acrolein into thoracic spinal cord produces acute and chronic injury and functional deficits.Determination of urine 3-HPMA, a stable acrolein metabolite in a rat model of spinal cord injury Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury A Reduction-Based Sensor for Acrolein Conjugates with the Inexpensive Nitrobenzene as an Alternative to Monoclonal Antibody.The effect of a polyurethane-based reverse thermal gel on bone marrow stromal cell transplant survival and spinal cord repair Elevated axonal membrane permeability and its correlation with motor deficits in an animal model of multiple sclerosis Acrolein scavengers: reactivity, mechanism and impact on health.Protein modification by acrolein: relevance to pathological conditions and inhibition by aldehyde sequestering agents.Role of lipid peroxidation-derived α, β-unsaturated aldehydes in vascular dysfunction.Contribution of PPARγ in modulation of acrolein-induced inflammatory signaling in gp91phox knock-out mice.Polyamine modification by acrolein exclusively produces 1,5-diazacyclooctanes: a previously unrecognized mechanism for acrolein-mediated oxidative stress.Perspectives on molecular biomarkers of oxidative stress and antioxidant strategies in traumatic brain injury.Allicin protects spinal cord neurons from glutamate-induced oxidative stress through regulating the heat shock protein 70/inducible nitric oxide synthase pathway.Time courses of post-injury mitochondrial oxidative damage and respiratory dysfunction and neuronal cytoskeletal degradation in a rat model of focal traumatic brain injury.Acrolein induces myelin damage in mammalian spinal cord.Protective effects of Vitamin C against spinal cord injury-induced renal damage through suppression of NF-κB and proinflammatory cytokines.CONTINUOUS INFUSION OF PHENELZINE, CYCLOSPORINE A OR THE COMBINATION: EVALUATION OF MITOCHONDRIAL BIOENERGETICS, OXIDATIVE DAMAGE AND CYTOSKELETAL DEGRADATION FOLLOWING SEVERE CONTROLLED CORTICAL IMPACT TRAUMATIC BRAIN INJURY IN RATS.

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Critical role of acrolein in secondary injury following ex vivo spinal cord trauma.

http://www.wikidata.org/entity/Q41879134

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2008 nî lūn-bûn

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Critical role of acrolein in secondary injury following ex vivo spinal cord trauma.

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Critical role of acrolein in secondary injury following ex vivo spinal cord trauma.

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Critical role of acrolein in secondary injury following ex vivo spinal cord trauma.

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J.1471-4159.2008.05622.X

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Journal of Neurochemistry

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Critical role of acrolein in secondary injury following ex vivo spinal cord trauma.

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Abigail Durkes

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Amber Pond

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Hui Ouyang

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Koji Uchida

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Kristin Hamann

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Riyi Shi

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P2860

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures.

Membrane resealing in cultured rat septal neurons after neurite transection: evidence for enhancement by Ca(2+)-triggered protease activity and cytoskeletal disassembly.

Current status of acrolein as a lipid peroxidation product.

Oxidation of polyamines and brain injury.

The molecular effects of acrolein.

Aldehyde-sequestering drugs: tools for studying protein damage by lipid peroxidation products.

Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations.

The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration.

Repair of plasmalemmal lesions by vesicles.

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10.1111/J.1471-4159.2008.05622.X

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3

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2671023

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