Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α. - sprookjes - yvandenbroek - TriplyDB

Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α.

Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α.

http://www.wikidata.org/entity/Q42185747

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Perforin and granzyme B have separate and distinct roles during atherosclerotic plaque development in apolipoprotein E knockout mice Granzyme B degrades extracellular matrix and contributes to delayed wound closure in apolipoprotein E knockout mice IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G Inflammasome activation of IL-1 family mediators in response to cutaneous photodamage The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines Redox control of senescence and age-related disease Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-β1 In vitro evaluation of a soluble Leishmania promastigote surface antigen as a potential vaccine candidate against human leishmaniasis Granzyme B releases vascular endothelial growth factor from extracellular matrix and induces vascular permeability.Serine protease inhibition attenuates rIL-12-induced GZMA activity and proinflammatory events by modulating the Th2 profile from estrogen-treated mice.Persistent release of IL-1s from skin is associated with systemic cardio-vascular disease, emaciation and systemic amyloidosis: the potential of anti-IL-1 therapy for systemic inflammatory diseases Caspase-1: the inflammasome and beyond.Granzyme-mediated regulation of host defense in the liver in experimental Leishmania donovani infection.TOE1 is an inhibitor of HIV-1 replication with cell-penetrating capability.The Inflammasome and the Epidermal Growth Factor Receptor (EGFR) Are Involved in the Staphylococcus aureus-Mediated Induction of IL-1alpha and IL-1beta in Human Keratinocytes.Granzyme B-expressing neutrophils correlate with bacterial load in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques.Interleukin-1α Activity in Necrotic Endothelial Cells Is Controlled by Caspase-1 Cleavage of Interleukin-1 Receptor-2: IMPLICATIONS FOR ALLOGRAFT REJECTION.Human S100A7 Induces Mature Interleukin1α Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis.Autophagy and IL-1 Family Cytokines.Uric acid as a danger signal in gout and its comorbidities Decoys and Regulatory "Receptors" of the IL-1/Toll-Like Receptor Superfamily.Secretory versus degradative autophagy: unconventional secretion of inflammatory mediators Redox-control of the alarmin, Interleukin-1α Redox control of the senescence regulator interleukin-1α and the secretory phenotype.Plasma granzyme B in ST elevation myocardial infarction versus non-ST elevation acute coronary syndrome: comparisons with IL-18 and fractalkine Interleukin 1α and the inflammatory process.Natural killer cell NKG2D and granzyme B are critical for allergic pulmonary inflammation.The role IL-1 in tumor-mediated angiogenesis.Granzyme K synergistically potentiates LPS-induced cytokine responses in human monocytes.The role of inflammasome-derived IL-1 in driving IL-17 responses.The role of inflammation and interleukin-1 in acute cerebrovascular disease.Blessing or curse? Proteomics in granzyme research.Cytokines and mucosal immunity.Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity.Interleukin-1α and brain inflammation.Interleukin-1 as a pharmacological target in acute brain injury.Unconventional Pathways of Secretion Contribute to Inflammation.Crosstalk between human DC subsets promotes antibacterial activity and CD8+ T-cell stimulation in response to bacille Calmette-Guérin.HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins

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Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α.

http://www.wikidata.org/entity/Q42185747

description

2011 nî lūn-bûn

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name

Granzyme B-dependent proteolys ...... nflammatory activity of IL-1α.

@en

Granzyme B-dependent proteolys ...... nflammatory activity of IL-1α.

@nl

type

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Granzyme B-dependent proteolys ...... nflammatory activity of IL-1α.

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Granzyme B-dependent proteolys ...... nflammatory activity of IL-1α.

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Granzyme B-dependent proteolys ...... nflammatory activity of IL-1α.

@en

Granzyme B-dependent proteolys ...... nflammatory activity of IL-1α.

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J.MOLCEL.2011.07.037

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Granzyme B-dependent proteolys ...... nflammatory activity of IL-1α.

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Alexander U Lüthi

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Emer P Reeves

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Graham A Tynan

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Inna S Afonina

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Jan P Medema

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Michael Bots

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Noel G McElvaney

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Sean P Cullen

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P2860

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase

Differential release of chromatin-bound IL-1alpha discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation

Selective release of a processed form of interleukin 1 alpha

A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

How dying cells alert the immune system to danger

Biologic basis for interleukin-1 in disease

Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1 alpha

Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B.

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265-278

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Seamus J. Martin

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51740309

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22017873

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3319689

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