about
Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studiesGenetic studies of body mass index yield new insights for obesity biologyPlatelet-reactivity tests identify patients at risk of secondary cardiovascular events: a systematic review and meta-analysisDirectional dominance on stature and cognition in diverse human populationsGenetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarizationAssociation between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant dataGenome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architectureGenetic Effects on the Correlation Structure of CVD Risk Factors: Exome-Wide Data From a Ghanaian Population.Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study.Human Validation of Genes Associated With a Murine Atherosclerotic Phenotype.Race/Ethnic Differences in the Associations of the Framingham Risk Factors with Carotid IMT and Cardiovascular Events.Genetic loci associated with heart rate variability and their effects on cardiac disease risk.Mendelian randomization of blood lipids for coronary heart disease.Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy.Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis.Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulationLarge-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations.Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes lociEpistatic interactions in genetic regulation of t-PA and PAI-1 levels in a Ghanaian population.Harnessing publicly available genetic data to prioritize lipid modifying therapeutic targets for prevention of coronary heart disease based on dysglycemic risk.Uniform data collection in routine clinical practice in cardiovascular patients for optimal care, quality control and research: The Utrecht Cardiovascular Cohort.Extending the use of GWAS data by combining data from different genetic platforms.A role for CETP TaqIB polymorphism in determining susceptibility to atrial fibrillation: a nested case control studySeparating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms.Monitoring initial response to Angiotensin-converting enzyme inhibitor-based regimens: an individual patient data meta-analysis from randomized, placebo-controlled trials.Bioinformatics challenges for genome-wide association studies.Genetic variants at chromosome 9p21 and risk of first versus subsequent coronary heart disease events: a systematic review and meta-analysis.Cardiovascular risk associated with interactions among polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systemsGene Set Enrichment Analyses: lessons learned from the heart failure phenotype.Discovery of novel heart rate-associated loci using the Exome Chip.52 Genetic Loci Influencing Myocardial Mass.Rs964184 (APOA5-A4-C3-A1) is related to elevated plasma triglyceride levels, but not to an increased risk for vascular events in patients with clinically manifest vascular disease.Genotype-specific pathogenic effects in human dilated cardiomyopathy.Robust association of the LPA locus with low-density lipoprotein cholesterol lowering response to statin treatment in a meta-analysis of 30 467 individuals from both randomized control trials and observational studies and association with coronary aAnnotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics.Measuring and targeting aldosterone and renin in atherosclerosis-a review of clinical data.Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.Dominant missense mutations in ABCC9 cause Cantú syndrome.
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description
Dutch cardiologist; professor of precision medicine in cardiovascular disease
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Nederlands onderzoeker
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Folkert W Asselbergs
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Folkert W Asselbergs
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