Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21. - sprookjes - yvandenbroek - TriplyDB

Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21.

Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21.

http://www.wikidata.org/entity/Q42526729

about

TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9 p53 Stabilization and accumulation induced by human vaccinia-related kinase 1 Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loop Multivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damage Targeting TBP-Associated Factors in Ovarian Cancer Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53 IIp45, an insulin-like growth factor binding protein 2 (IGFBP-2) binding protein, antagonizes IGFBP-2 stimulation of glioma cell invasion.Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway.Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation.The 9aaTAD Transactivation Domains: From Gal4 to p53.Inhibiting the p53-MDM2 interaction: an important target for cancer therapy.Insulin-like growth factor binding protein 2 promotes glioma development and progression Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation Phosphorylation-induced Conformational Ensemble Switching in an Intrinsically Disordered Cancer/Testis Antigen.Phosphorylation of Thr18 and Ser20 of p53 in Ad-p53-induced apoptosis.Identification of new p53 acetylation sites in COS-1 cells.Walleye dermal sarcoma virus rv-cyclin inhibits NF-kappaB-dependent transcription.IGFBP2 is a candidate biomarker for Ink4a-Arf status and a therapeutic target for high-grade gliomas.OGlcNAcylation and phosphorylation have similar structural effects in α-helices: post-translational modifications as inducible start and stop signals in α-helices, with greater structural effects on threonine modification.Structural details on mdm2-p53 interaction.Defective p53 post-translational modification required for wild type p53 inactivation in malignant epithelial cells with mdm2 gene amplification.Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development.

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P2860

Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21.

http://www.wikidata.org/entity/Q42526729

description

2002 nî lūn-bûn

@nan

2002年の論文

@ja

2002年学术文章

@wuu

2002年学术文章

@zh-cn

2002年学术文章

@zh-hans

2002年学术文章

@zh-my

2002年学术文章

@zh-sg

2002年學術文章

@yue

2002年學術文章

@zh

2002年學術文章

@zh-hant

name

Mdm-2 binding and TAF

@nl

Mdm-2 binding and TAF(II)31 re ...... p53 residues Thr18 and Asp21.

@en

type

label

Mdm-2 binding and TAF

@nl

Mdm-2 binding and TAF(II)31 re ...... p53 residues Thr18 and Asp21.

@en

prefLabel

Mdm-2 binding and TAF

@nl

Mdm-2 binding and TAF(II)31 re ...... p53 residues Thr18 and Asp21.

@en

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Mdm-2 binding and TAF(II)31 re ...... p53 residues Thr18 and Asp21.

@en

P2093

Amy D Tabor

http://www.w3.org/2001/XMLSchema#string

Guillermina Lozano

http://www.w3.org/2001/XMLSchema#string

Hua Wang

http://www.w3.org/2001/XMLSchema#string

James R Jabbur

http://www.w3.org/2001/XMLSchema#string

Motonari Uesugi

http://www.w3.org/2001/XMLSchema#string

Wei Zhang

http://www.w3.org/2001/XMLSchema#string

Xiaodong Cheng

http://www.w3.org/2001/XMLSchema#string

P2860

A role for ATR in the DNA damage-induced phosphorylation of p53

GADD45 induction of a G2/M cell cycle checkpoint

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

Divergent hTAFII31-binding motifs hidden in activation domains

Wild-type p53 binds to the TATA-binding protein and represses transcription

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

Synergistic activation of transcription by CBP and p53

Binding and modulation of p53 by p300/CBP coactivators

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

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scholarly article

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10.1038/SJ.ONC.1205856

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46

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21

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2002-10-01T00:00:00Z

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11088612

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1053467781

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