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Gene, Stem Cell, and Alternative Therapies for SCA 1Cell biology of spinocerebellar ataxiaBeyond the glutamine expansion: influence of posttranslational modifications of ataxin-1 in the pathogenesis of spinocerebellar ataxia type 1The unstable repeats--three evolving faces of neurological diseaseRAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1Dopamine D2 receptor signaling modulates mutant ataxin-1 S776 phosphorylation and aggregation.Stabilization and Degradation Mechanisms of Cytoplasmic Ataxin-1.Perturbation of the Akt/Gsk3-β signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs.14-3-3 Binding to ataxin-1(ATXN1) regulates its dephosphorylation at Ser-776 and transport to the nucleus.A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1.SCA1-phosphorylation, a regulator of Ataxin-1 function and pathogenesis.Cerebellar Transcriptome Profiles of ATXN1 Transgenic Mice Reveal SCA1 Disease Progression and Protection Pathways.Post-translational Modifications and Protein Quality Control in Motor Neuron and Polyglutamine Diseases.The design and delivery of a PKA inhibitory polypeptide to treat SCA1.Adenylyl cyclase activating polypeptide reduces phosphorylation and toxicity of the polyglutamine-expanded androgen receptor in spinobulbar muscular atrophy.Short-term succinic acid treatment mitigates cerebellar mitochondrial OXPHOS dysfunction, neurodegeneration and ataxia in a Purkinje-specific spinocerebellar ataxia type 1 (SCA1) mouse model.Polyglutamine spinocerebellar ataxias - from genes to potential treatments.Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model.PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in Spinocerebellar ataxia type 1.Roles of Post-translational Modifications in Spinocerebellar Ataxias
P2860
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P2860
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Phosphorylation of ATXN1 at Ser776 in the cerebellum.
@en
Phosphorylation of ATXN1 at Ser776 in the cerebellum.
@nl
type
label
Phosphorylation of ATXN1 at Ser776 in the cerebellum.
@en
Phosphorylation of ATXN1 at Ser776 in the cerebellum.
@nl
prefLabel
Phosphorylation of ATXN1 at Ser776 in the cerebellum.
@en
Phosphorylation of ATXN1 at Ser776 in the cerebellum.
@nl
P2093
P2860
P50
P1476
Phosphorylation of ATXN1 at Ser776 in the cerebellum.
@en
P2093
Ben Armstrong
Courtney E Byam
H Brent Clark
J Michael Andresen
Lisa A Duvick
Nathan D Jorgensen
Paymaan Jafar-Nejad
Sam Stevens
Sara Lagalwar
P2860
P304
P356
10.1111/J.1471-4159.2009.06164.X
P407
P577
2009-05-15T00:00:00Z