Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment.
about
Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2CASK Functions as a Mg2+-independent neurexin kinaseLY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft modelsIdentifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinasesMNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages.Exploring aigialomycin d and its analogues as protein kinase inhibitors for cancer targets.Induction of viral, 7-methyl-guanosine cap-independent translation and oncolysis by mitogen-activated protein kinase-interacting kinase-mediated effects on the serine/arginine-rich protein kinase.Type I interferon (IFN)-dependent activation of Mnk1 and its role in the generation of growth inhibitory responses.Targeting Mnks for cancer therapy.Targeting the unactivated conformations of protein kinases for small molecule drug discovery.Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction.Unveiling new chemical scaffolds as Mnk inhibitors.MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1.Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors: synthesis, SAR analysis and biological evaluation.Dynamical insights of Mnk2 kinase activation by phosphorylation to facilitate inhibitor discovery.Insights into the Importance of DFD-Motif and Insertion I1 in Stabilizing the DFD-Out Conformation of Mnk2 KinaseThe C-terminal domain of Mnk1a plays a dual role in tightly regulating its activity.Small Molecules Targeting the Inactive Form of the Mnk1/2 Kinases.
P2860
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P2860
Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Mitogen-activated protein kina ...... programmed activation segment.
@en
Mitogen-activated protein kina ...... programmed activation segment.
@nl
type
label
Mitogen-activated protein kina ...... programmed activation segment.
@en
Mitogen-activated protein kina ...... programmed activation segment.
@nl
prefLabel
Mitogen-activated protein kina ...... programmed activation segment.
@en
Mitogen-activated protein kina ...... programmed activation segment.
@nl
P2093
P2860
P50
P356
P1433
P1476
Mitogen-activated protein kina ...... programmed activation segment.
@en
P2093
Babette Aicher
Catharina Netter
Herbert Jäckle
Kay Schreiter
Ralf Jauch
Stefan Jäkel
P2860
P304
P356
10.1038/SJ.EMBOJ.7601285
P407
P577
2006-08-17T00:00:00Z