Structural design, solid-phase synthesis and activity of membrane-anchored β-secretase inhibitors on Aβ generation from wild-type and Swedish-mutant APP.

Structural design, solid-phase synthesis and activity of membrane-anchored β-secretase inhibitors on Aβ generation from wild-type and Swedish-mutant APP.

Item
http://www.wikidata.org/entity/Q42785839
Brain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeuticFocusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer's diseaseMass spectrometric analysis of nanoscale sample volumes extracted from open microchannels after sample preconcentration applied on amyloid beta peptides.Cerebrospinal fluid amyloid-β 2-42 is decreased in Alzheimer's, but not in frontotemporal dementiaGeneration of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site.The Metalloprotease Meprin β Is an Alternative β-Secretase of APP.Solid-Phase Synthesis and Characterization of N-Terminally Elongated Aβ-3-x -Peptides.Insights into the Impact of a Membrane-Anchoring Moiety on the Biological Activities of Bivalent Compounds As Potential Neuroprotectants for Alzheimer's Disease.Optimisation of BACE1 inhibition of tripartite structures by modification of membrane anchors, spacers and pharmacophores - development of potential agents for the treatment of Alzheimer's disease.An infrared sensor analysing label-free the secondary structure of the Abeta peptide in presence of complex fluids.
P2860

Structural design, solid-phase synthesis and activity of membrane-anchored β-secretase inhibitors on Aβ generation from wild-type and Swedish-mutant APP.

Item
http://www.wikidata.org/entity/Q42785839
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Structural design, solid-phase ...... d-type and Swedish-mutant APP.
@en
Structural design, solid-phase ...... d-type and Swedish-mutant APP.
@nl
type
label
Structural design, solid-phase ...... d-type and Swedish-mutant APP.
@en
Structural design, solid-phase ...... d-type and Swedish-mutant APP.
@nl
prefLabel
Structural design, solid-phase ...... d-type and Swedish-mutant APP.
@en
Structural design, solid-phase ...... d-type and Swedish-mutant APP.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P356
P1433
P1476
Structural design, solid-phase ...... d-type and Swedish-mutant APP.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698