about
Rarity of the Alzheimer disease-protective APP A673T variant in the United StatesDevelopmentally regulated expression of pleiotrophin, a novel heparin binding growth factor, in the nervous system of the ratNeuregulin-1beta induces neurite extension and arborization in cultured hippocampal neuronsCommon variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.Molecular mechanisms promoting the pathogenesis of Schwann cell neoplasmsA liquid chromatography mass spectrometry assay for determination of PD168393, a specific and irreversible inhibitor of erbB membrane tyrosine kinases, in rat serumTamoxifen inhibits malignant peripheral nerve sheath tumor growth in an estrogen receptor-independent mannerKnockout of plasminogen activator inhibitor 1 gene reduces amyloid beta peptide burden in a mouse model of Alzheimer's disease.Orthotopic xenografting of human luciferase-tagged malignant peripheral nerve sheath tumor cells for in vivo testing of candidate therapeutic agents.Genetically engineered mouse models shed new light on the pathogenesis of neurofibromatosis type I-related neoplasms of the peripheral nervous system.The pan erbB inhibitor PD168393 enhances lysosomal dysfunction-induced apoptotic death in malignant peripheral nerve sheath tumor cellsNovel late-onset Alzheimer disease loci variants associate with brain gene expression.Malignant peripheral nerve sheath tumor invasion requires aberrantly expressed EGF receptors and is variably enhanced by multiple EGF family ligands.Transgenic mice overexpressing neuregulin-1 model neurofibroma-malignant peripheral nerve sheath tumor progression and implicate specific chromosomal copy number variations in tumorigenesisNeuregulin-1 enhances survival of human astrocytic glioma cells.Neuregulin-1 beta and neuregulin-1 alpha differentially affect the migration and invasion of malignant peripheral nerve sheath tumor cells.Constitutive activation of the neuregulin-1/erbB signaling pathway promotes the proliferation of a human peripheral neuroepithelioma cell line.Constitutive activation of the neuregulin-1/ErbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line.Neuregulin-1beta modulates in vivo entorhinal-hippocampal synaptic transmission in adult rats.ErbB transmembrane tyrosine kinase receptors are expressed by sensory and motor neurons projecting into sciatic nerve.Improved gene delivery into neuroglial cells using a fiber-modified adenovirus vector.Activation of the neuregulin-1/ErbB signaling pathway promotes the proliferation of neoplastic Schwann cells in human malignant peripheral nerve sheath tumors.Neuregulin growth factors and their ErbB receptors form a potential signaling network for schwannoma tumorigenesis.Neuregulin-1 enhances motility and migration of human astrocytic glioma cells.Dorsal root ganglion neurons expressing trk are selectively sensitive to NGF deprivation in utero.BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death.Parsing out reality from genetically engineered mouse models of neurologic diseases.Exchange assay for androgen receptors in the presence of molybdate.Neuropathy of metachromatic leukodystrophy: Improvement with immunomodulationErbB4 promotes malignant peripheral nerve sheath tumor pathogenesis via Ras-independent mechanismsThe evolution and multi-molecular properties of NF1 cutaneous neurofibromas originating from C-fiber sensory endings and terminal Schwann cells at normal sites of sensory terminations in the skin
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Steven Carroll
@ast
Steven Carroll
@en
Steven Carroll
@es
Steven Carroll
@nl
Steven Carroll
@sl
type
label
Steven Carroll
@ast
Steven Carroll
@en
Steven Carroll
@es
Steven Carroll
@nl
Steven Carroll
@sl
prefLabel
Steven Carroll
@ast
Steven Carroll
@en
Steven Carroll
@es
Steven Carroll
@nl
Steven Carroll
@sl
P106
P1153
7201476352
P21
P31
P496
0000-0001-6714-4373