about
Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemiaThe tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemiaTribbles in acute leukemiaHuman TRIB2 Oscillates during the Cell Cycle and Promotes Ubiquitination and Degradation of CDC25CTransformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 bindingTribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease.Nfix expression critically modulates early B lymphopoiesis and myelopoiesisDistinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor.Co-operative leukemogenesis in acute myeloid leukemia and acute promyelocytic leukemia reveals C/EBPα as a common target of TRIB1 and PML/RARA.The functionally diverse roles of tribbles.Insights into cell ontogeny, age, and acute myeloid leukemia.TRIB2 and the ubiquitin proteasome system in cancer.Unlocking the potential of anti-CD33 therapy in adult and childhood acute myeloid leukemia.The presence of C/EBPα and its degradation are both required for TRIB2-mediated leukaemia.The Tribble with APL: A New Road to Therapy.Regulation of NF-κB by PML and PML-RARα.Bcr-Abl upregulates cytosolic p21WAF-1/CIP-1 by a phosphoinositide-3-kinase (PI3K)-independent pathway.Transcription activation function of C/EBPalpha is required for induction of granulocytic differentiation.TRIB2 regulates normal and stress-induced thymocyte proliferation.Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently suppressed by C/EBPalpha.Regulation of Trib2 by an E2F1-C/EBPα feedback loop in AML cell proliferation.High Bcr-Abl expression prevents the translocation of Bax and Bad to the mitochondrion.Negative regulation of TLX by IL-1β correlates with an inhibition of adult hippocampal neural precursor cell proliferation.Tribbles homolog 2 (Trib2) and HoxA9 cooperate to accelerate acute myelogenous leukemia.A Trib2-p38 axis controls myeloid leukaemia cell cycle and stress response signalling.Elevated TRIB2 with NOTCH1 activation in paediatric/adult T-ALL.Trib2 expression in granulocyte-monocyte progenitors drives a highly drug resistant acute myeloid leukaemia linked to elevated Bcl2.Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemiasCovalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells.Repurposing covalent EGFR/HER2 inhibitors for on-target degradation of human Tribbles 2 (TRIB2) pseudokinaseInverse and correlative relationships between TRIBBLES genes indicate non-redundant functions during normal and malignant hemopoiesisHarnessing the potential of epigenetic therapies for childhood acute myeloid leukemiaKnockdown of interleukin-1 receptor 1 is not neuroprotective in the 6-hydroxydopamine striatal lesion rat model of Parkinson's diseasePseudokinases: a tribble-edged sword
P50
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P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Karen Keeshan
@ast
Karen Keeshan
@en
Karen Keeshan
@es
Karen Keeshan
@nl
Karen Keeshan
@sl
type
label
Karen Keeshan
@ast
Karen Keeshan
@en
Karen Keeshan
@es
Karen Keeshan
@nl
Karen Keeshan
@sl
prefLabel
Karen Keeshan
@ast
Karen Keeshan
@en
Karen Keeshan
@es
Karen Keeshan
@nl
Karen Keeshan
@sl
P1053
L-5615-2013
P106
P2038
Karen_Keeshan
P21
P31
P3829
P3835
karen-keeshan
P496
0000-0001-7266-0890