The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.
about
Cdx4 and menin co-regulate Hoxa9 expression in hematopoietic cellsCrystal structure of menin reveals binding site for mixed lineage leukemia (MLL) proteinHigh-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein InteractionMenin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemiaMolecular basis of the mixed lineage leukemia-menin interaction: implications for targeting mixed lineage leukemias.Menin interacts with IQGAP1 to enhance intercellular adhesion of beta-cells.Novel insight into mutational landscape of head and neck squamous cell carcinomaDistribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation.Suppression of lung adenocarcinoma through menin and polycomb gene-mediated repression of growth factor pleiotrophin.MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.Regulation of cyclin B2 expression and cell cycle G2/m transition by meninMenin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome.Clinical and molecular genetics of parathyroid neoplasmsPAFc, a key player in MLL-rearranged leukemogenesis.Regression analysis of combined gene expression regulation in acute myeloid leukemiaModulation by miR-29b of intestinal epithelium homoeostasis through the repression of menin translation.DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesisParathyroid tumor development involves deregulation of homeobox genesChallenges and opportunities in targeting the menin-MLL interaction.Menin represses tumorigenesis via repressing cell proliferation.Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells.Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10Menin induces endodermal differentiation in aggregated P19 stem cells by modulating the retinoic acid receptors.In search of tumor suppressing functions of meninMenin mediates epigenetic regulation via histone H3 lysine 9 methylation.The trithorax protein partner menin acts in tandem with EZH2 to suppress C/EBPα and differentiation in MLL-AF9 leukemia.Tumor Suppressors and Endodermal Differentiation of P19 Embryonic Stem Cells.Menin regulates the function of hematopoietic stem cells and lymphoid progenitors.Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells.Menin critically links MLL proteins with LEDGF on cancer-associated target genesEssential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia.In vitro hematopoietic differentiation of mouse embryonic stem cells requires the tumor suppressor menin and is mediated by Hoxa9.Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective.Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1.Multiple endocrine neoplasia type 1 (MEN1): not only inherited endocrine tumors.MLL-Rearranged Leukemias-An Update on Science and Clinical Approaches.Tumorigenicity of Ewing sarcoma is critically dependent on the trithorax proteins MLL1 and menin.The Menin-Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis.Epigenetic regulations in hematopoietic Hox code.The heterogeneity of pediatric MLL-rearranged acute myeloid leukemia.
P2860
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P2860
The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.
description
2006 nî lūn-bûn
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2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年论文
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name
The tumor suppressor menin reg ...... nfluencing Hox gene expression
@nl
The tumor suppressor menin reg ...... fluencing Hox gene expression.
@ast
The tumor suppressor menin reg ...... fluencing Hox gene expression.
@en
type
label
The tumor suppressor menin reg ...... nfluencing Hox gene expression
@nl
The tumor suppressor menin reg ...... fluencing Hox gene expression.
@ast
The tumor suppressor menin reg ...... fluencing Hox gene expression.
@en
prefLabel
The tumor suppressor menin reg ...... nfluencing Hox gene expression
@nl
The tumor suppressor menin reg ...... fluencing Hox gene expression.
@ast
The tumor suppressor menin reg ...... fluencing Hox gene expression.
@en
P2093
P2860
P50
P921
P356
P1476
The tumor suppressor menin reg ...... fluencing Hox gene expression.
@en
P2093
Albert Silva
Eric J Brown
Haoren Wang
Jay L Hess
Warren S Pear
Xianxin Hua
Ya-Xiong Chen
P2860
P304
P356
10.1073/PNAS.0510347103
P407
P577
2006-01-13T00:00:00Z